ImmunologybioRxiv
Regulation of lipid accumulation-induced ROS in myeloid-derived suppressor cells via targeting fatty-acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy
A. O. Adeshakin, W. Liu, F. O. Adeshakin…·X. Wan
This study shows that inhibiting FATP2 in MDSCs reduces ROS and enhances anti-PD-L1 immunotherapy by improving T-cell function and reducing PD-L1 expression.
DOI 10.1016/j.cellimm.2021.104286