T. Anderson

Interfering with nucleotide excision by the coronavirus 3'-to-5' exoribonuclease

This study investigates how SARS-CoV-2's ExoN enzyme processes RNA and identifies modifications that block its activity, offering potential for new antiviral strategies.

Contribution of SARS-CoV-2 accessory proteins to viral pathogenicity in K18 hACE2 transgenic mice

This study identifies ORF3a and ORF6 as key contributors to SARS-CoV-2 pathogenesis in mice using a reverse genetics system and K18 hACE2 transgenic mice.

P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites

This study examines K13 mutations in Plasmodium falciparum, showing varying degrees of artemisinin resistance and fitness costs in African parasites, while finding no significant impact on ART susceptibility in Southeast Asian strains.

Generation and Characterization of recombinant SARS-CoV-2 expressing reporter genes

This paper generates and characterizes recombinant SARS-CoV-2 viruses expressing fluorescent or bioluminescent reporter genes, demonstrating their utility for tracking viral infection and screening therapeutics.

Characterising the methylome of Legionellalongbeachae serogroup 1 clinical isolates and assessing geo-temporal genetic diversity

The paper sequences and analyzes the genetic and methylome diversity of 54 L. longbeachae clinical isolates, revealing two main clades and epigenetic modifications associated with specific DNA motifs.

Rescue of SARS-CoV-2 from a single bacterial artificial chromosome

The paper develops an infectious SARS-CoV-2 cDNA clone using a bacterial artificial chromosome, which replicates similarly to the natural virus in cell cultures and animal models.

Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

The hemolymph of Biomphalaria snail vectors of schistosomiasis supports a diverse microbiome

The paper analyzes the microbiome of Biomphalaria snail hemolymph to understand its composition and potential role in schistosomiasis transmission.

The extended recovery ring stage survival assay provides superior prediction of patient clearance half life and increases throughput

The paper introduces an improved ring-stage survival assay (eRRSA) that better predicts patient clearance half-life and increases throughput for artemisinin resistance testing.

Bridging micro and macro: accurate registration of the BigBrain dataset with the MNI PD25 and ICBM152 atlases

The paper registers the BigBrain atlas with MNI PD25 and ICBM152 atlases to bridge histological and MRI data for neurological research and surgery.

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

The paper identifies genetic determinants of Plasmodium falciparum fitness across its life cycle using bulk segregant analysis and experimental crosses.