D. Bailey

Global variation in prior exposure shapes antibody neutralization profiles of SARS-CoV-2 variants up to BA.2.86

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

Viral pIC-pocketing: RSV sequestration of eIF4F Initiation Complexes into bi-phasic biomolecular condensates

This study identifies a mechanism by which RSV sequesters eIF4F initiation complex components into bi-phasic inclusion bodies to facilitate viral mRNA translation.

An alpaca-derived nanobody neutralizes the SARS-CoV-2 omicron variant

This paper identifies a nanobody that effectively neutralizes the SARS-CoV-2 Omicron variants BA.1 and BA.2, showing high affinity and pre-clinical promise.

Distinct antigenic properties of the SARS-CoV-2 Omicron lineages BA.4 and BA.5

This study compares the antigenic properties of SARS-CoV-2 Omicron variants BA.4 and BA.5 with BA.1, BA.2, and vaccine-induced antibodies, finding they are antigenically distinct and show enhanced neutralisation breadth after breakthrough infection.

An ACAT inhibitor regulates SARS-CoV-2 replication and antiviral T cell activity

This paper shows that ACAT inhibitors like Avasimibe reduce SARS-CoV-2 replication and enhance antiviral T cell activity in patients.

The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein

This study identifies distinct genetic determinants in the Omicron spike protein for altered cell entry and antigenic properties, showing they are separable and may affect future variant severity and vaccine efficacy.

SARS-CoV-2 variants of concern Alpha, Beta, Gamma and Delta have extended ACE2 receptor host-ranges

The paper examines whether SARS-CoV-2 variants Alpha, Beta, Gamma, and Delta have altered ACE2 receptor usage across different mammalian species, finding that N501Y and E484K substitutions in the Spike RBD expand their host range.

Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.

The paper identifies spike mutations that adapt SARS-CoV-2 to mustelid hosts and assesses their impact on human infectivity and antigenicity.

Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected Patients

This study shows that convalescent sera from SARS-CoV-2 infected patients efficiently neutralize RaTG13, a close coronavirus relative, more effectively than SARS-CoV-2 itself.

The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 Beta (B.1.351) and other variants of concern in preclinical studies.

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

This study shows BMAL1 regulates ACE2 expression and SARS-CoV-2 entry in lung epithelial cells, with SR9009 reducing viral replication through circadian mechanisms.

Design, construction, and deployment of an affordable and long-lasting moored deep-water fish aggregation device

The paper describes the design and deployment of a durable, affordable deep-water FAD and discusses its potential as a scientific tool for pelagic species research and conservation.

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

This study shows that a booster dose of the ChAdOx1 nCoV-19 vaccine increases immune response in aged mice compared to a single dose.

Respiratory syncytial virus sequesters NF-κB subunit p65 to cytoplasmic inclusion bodies to inhibit innate immune signalling

This paper identifies that RSV sequesters the NF-κB subunit p65 to cytoplasmic inclusion bodies to inhibit innate immune signalling, a mechanism conserved across the Orthopneumovirus genus.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

This study shows SARS-CoV-2 Spike protein can bind to ACE2 receptors from multiple mammals, indicating broad host tropism and potential for zoonotic transmission.

A novel antiviral formulation inhibits a range of enveloped viruses.

This study evaluates a novel antiviral formulation, ViroSAL, which inhibits multiple enveloped viruses in vitro and in vivo by disrupting viral envelopes.

Elevated intracellular cAMP concentration mediates growth suppression in glioma cells

The paper shows that increasing intracellular cAMP levels via AC activation or PDE inhibition suppresses glioma cell growth, with different mechanisms depending on the PDE inhibitor used.

Full-featured, real-time database searching platform enables fast and accurate multiplexed quantitative proteomics.

The paper introduces a real-time database search platform, Orbiter, that improves the efficiency and accuracy of multiplexed quantitative proteomics by reducing data acquisition time and increasing protein quantification.

Murine norovirus virulence factor 1 (VF1) protein contributes to viral fitness during persistent infection

This study shows that VF1 in MNV contributes to viral fitness during persistent infection but is not essential for persistence.

Viral infection enhances vomocytosis of intracellular fungi via Type I interferons

This paper shows that viral infection increases vomocytosis of Cryptococcus neoformans by macrophages through type-I interferons.