Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair
G. Ali, R. Zhao, M. Zhang, K. G. Jain, J. Chang, S. Komatsu, X. Fang, B. Zhou, J. Liang, D. Jiang, M. Ikebe, M. A. Matthay, H.-L. Ji
This study shows that the fibrinolytic niche regulates alveolar type 2 cell function and regeneration through the uPA-A6-CD44-ENaC cascade, with implications for lung injury repair.
bioRxiv · Mar 24, 2020 · PreprintCell Biology