Author

K. E. Dingle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 5 Approach:statistical model· 3 Research Focus:variant calling· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:phylogenetics / evolution· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1

Frequent Co-Authors

A. S. Walker· 4 shared D. W. Crook· 4 shared D. W. Eyre· 3 shared T. E. Peto· 3 shared X. Didelot· 3 shared E. Robinson· 2 shared M. H. Wilcox· 2 shared M. Morgan· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersMicrobiology

A. S. Walker

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Author profile →

5 papers

Recent·Most cited

Penicillin Binding Protein Substitutions Co-occur with Fluoroquinolone Resistance in 'Epidemic Lineages of Multi Drug-Resistant Clostridioides difficile

K. E. Dingle, J. Freeman, X. Didelot, D. W. Eyre, J. Swann, W. Spittal, E. V. Clark, K. A. Jolley, A. S. Walker, M. H. Wilcox, D. W. Crook

The paper identifies amino acid substitutions in penicillin binding proteins (PBPs) PBP1 and PBP3 as a mechanism of cephalosporin resistance in C. difficile, which co-occurs with fluoroquinolone resistance in epidemic lineages.

bioRxiv · May 23, 2022 · PreprintMicrobiology

The Clostridioides difficile species problem: global phylogenomic analysis uncovers three ancient, toxigenic, genomospecies

D. R. Knight, K. Imwattana, B. Kullin, E. Guerrero-Araya, D. Paredes-Sabja, X. Didelot, K. E. Dingle, D. W. Eyre, C. Rodriguez, T. V. Riley

This study identifies three ancient, toxigenic genomospecies within C. difficile using global phylogenomic analysis, reshaping its taxonomy and understanding of toxin gene evolution.

bioRxiv · Sep 21, 2020Microbiology

DNA Thermo-Protection Facilitates Whole Genome Sequencing of Mycobacteria Direct from Clinical Samples by the Nanopore Platform

S. George, Y. Xu, G. Rodger, M. Morgan, N. D. Sanderson, S. Hoosdally, S. Thulborn, E. Robinson, P. Rathod, A. S. Walker, T. E. Peto, D. W. Crook, K. E. Dingle

This paper develops a thermo-protection buffer to enable direct whole genome sequencing of Mycobacteria from clinical samples using Nanopore technology, achieving high coverage at low bacterial concentrations.

bioRxiv · Apr 5, 2020 · PreprintMicrobiology

MinION Nanopore Sequencing of Multiple Displacement Amplified Mycobacteria DNA Direct from Sputum

S. George, Y. Xu, N. Sanderson, A. T. Hubbard, D. T. Griffiths, M. Morgan, L. Pankhurst, S. J. Hoosdally, D. Foster, S. Thulborn, E. Robinson, E. G. Smith, P. Rathod, A. S. Walker, T. E. Peto, , K. E. Dingle

This study evaluates the effectiveness of multiple displacement amplification followed by MinION sequencing for detecting Mycobacteria DNA in sputum samples.

bioRxiv · Dec 7, 2018 · PreprintMicrobiology

A role for tetracycline selection in the evolution of Clostridium difficile PCR-ribotype 078

K. E. Dingle, X. Didelot, T. P. Quan, D. W. Eyre, N. Stoesser, C. A. Marwick, J. Coia, D. Brown, S. Buchanan, U. Z. Ijaz, C. Goswami, G. Douce, W. N. Fawley, M. H. Wilcox, T. E. Peto, , D. W. Crook

The paper investigates the evolutionary history of Clostridium difficile RT078, finding that tetracycline resistance genes, particularly tetM, were acquired independently in multiple clonal expansions, contributing to its increased prevalence.

bioRxiv · Feb 8, 2018Microbiology