G. J. Randolph

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

This study shows that pancreas resident macrophages (TRMs) have distinct roles in pancreatitis and pancreatic cancer, promoting fibrosis in inflammation but driving cancer progression.

This study shows intestinal HDL neutralizes LPS in the portal vein, protecting the liver from injury in a mouse model of short bowel syndrome.

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

This study shows that a CXCR4-binding PET tracer accumulates in atherosclerotic plaques due to endothelial CXCR4 expression, linking endothelial injury to monocyte recruitment.

This study identifies shared and unique features between peripheral nerve macrophages and CNS microglia, showing PNS macrophages express genes associated with microglial activation.