A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells
O. Baba, F. Zou, T. Horie, Y. Nakashima, S. Tsuji, T. Yamasaki, C. Otani, S. Xu, M. Imanaka, K. Matsushita, K. Suzuki, E. Kume, H. Kojima, Q. Qian, K. Kimura, , K. Ono
This study shows that KUS121 reduces atherosclerosis by maintaining ATP levels and reducing ER stress in endothelial cells.
bioRxiv · Apr 29, 2024 · PreprintPathology