Author

C. Zuo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 2 Bioengineering· 1 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

B. L. Knolhoff· 3 shared J. M. Baer· 3 shared A. Alarcon de la Lastra· 2 shared D. G. DeNardo· 2 shared G. D. Hogg· 2 shared J. Mao· 2 shared J. Yang· 2 shared J. Zhu· 2 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCancer Biology

B. L. Knolhoff

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Understanding Vascular Endothelial Cell Behavior Using a Mechanical Strain Gradient Generated by an Electromagnetic Stretching Device

M. L. Yang, C. Zuo, J. Liu, K. Man, Z. Zuo, Y. Yang

This study develops an electromagnetic stretching device to apply controlled mechanical strain to endothelial cells, revealing strain-dependent cellular and nuclear orientation and the effects of overstretching on endothelial function.

bioRxiv · Oct 20, 2022 · PreprintBioengineering

Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-COV-2 Delta Variant

K. Huang, N. Li, Y. Li, J. Zhu, Q. Fan, J. Yang, Y. Gao, Y. Liu, Q. Hou, S. Gao, K. Wei, C. Deng, C. Zuo, Z. Sun

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

bioRxiv · May 12, 2022 · PreprintImmunology

Context-dependent triggering of STING-interferon signaling by CD11b agonists supports anti-tumor immunity in mouse models and human cancer patients

X. Liu, G. D. Hogg, c. zuo, J. M. Baer, V. E. Lander, L. Kang, N. C. Borcherding, B. L. Knolhoff, R. E. Osterhout, A. V. Galkin, J. M. Bruey, L. L. Carter, C. Mpoy, J. K. Schwarz, H. Park, , D. DeNardo

This study identifies how CD11b agonists trigger STING-interferon signaling in tumor-associated macrophages to enhance anti-tumor immunity in mouse models and human cancer patients.

bioRxiv · Mar 22, 2022 · PreprintCancer Biology

Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC

J. M. Baer, C. Zuo, L.-I. Kang, A. Alarcon de la Lastra, N. C. Borcherding, B. L. Knolhoff, S. J. Bogner, Y. Zhu, M. A. Lewis, N. Zhang, K.-w. Kim, R. C. Fields, J. C. Mills, L. Ding, G. J. Randolph, D. G. DeNardo

This study shows that pancreas resident macrophages (TRMs) have distinct roles in pancreatitis and pancreatic cancer, promoting fibrosis in inflammation but driving cancer progression.

bioRxiv · Feb 9, 2022 · PreprintImmunology

Macrophage proliferation machinery leads to PDAC progression, but susceptibility to innate immunotherapy.

D. G. DeNardo, C. Zuo, J. M. Baer, B. L. Knolhoff, J. I. Belle, X. Liu, G. D. Hogg, C. Fu, N. L. Kingston, M. A. Brenden, A. Alarcon De La Lastra, P. B. Dodhiawala, C. Zhou, A. James, L. Ding, , J. D. Weber

This study shows that TAM proliferation in PDAC is driven by CSF1 from fibroblasts, leading to immunosuppression and tumor progression, but also increasing sensitivity to CD40 agonist therapy.

bioRxiv · Nov 8, 2021 · PreprintCancer Biology

Intratumoral Delivered Novel Circular mRNA Encoding Cytokines for Immune Modulation and Cancer Therapy

J. Yang, J. Zhu, Y. Chen, Y. Du, Y. Tan, L. Wu, J. Sun, M. Zhai, L. Wei, N. Li, K. Huang, Q. Hou, Z. Tong, A. Bechthold, Z. Sun, C. Zuo

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

bioRxiv · Nov 1, 2021Cancer Biology

Structural Insights Into the Initiation and Elongation of Ubiquitination by Ubr1

M. Pan, Q. Zheng, T. Wang, L. Liang, J. Mao, C. Zuo, R. Ding, H. Ai, Y. Xie, D. Si, Y. Yu, L. Liu, M. Zhao

This study reports cryo-EM structures of Ubr1 complexes to elucidate the mechanism of ubiquitination initiation and elongation using a single E2 enzyme.

bioRxiv · Apr 12, 2021 · PreprintBiophysics

Spatial drivers and pre-cancer populations collaborate with the microenvironment in untreated and chemo-resistant pancreatic cancer

D. Cui Zhou, R. G. Jayasinghe, J. M. Herndon, E. Storrs, C.-K. Mo, Y. Wu, R. S. Fulton, M. A. Wyczalkowski, C. C. Fronick, L. A. Fulton, L. Thammavong, K. Sato, H. Zhu, H. Sun, L.-B. Wang, , Ch

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.

bioRxiv · Jan 13, 2021Cancer Biology

Effects of CEPA and 1-MCP on flower bud differentiation of apple cv. ‘Nagafu No.2’ grafted on different rootstocks

W. Li, B. Chen, J. Mao, X. Li, J. Su, M. M. Dawuda, Z. Ma, C. Zuo, Z. An

This study examines the effects of CEPA and 1-MCP on flower bud differentiation in apple trees grafted on different rootstocks, finding CEPA promotes flowering while 1-MCP has no significant effect.

bioRxiv · Mar 13, 2018Physiology