MicrobiologybioRxiv
Ubiquitin-like cGAS chain formation by a super enzyme activates anti-phage response
Y. Yan, J. Xiao, F. Huang…·B. Zhu
This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.
DOI 10.1038/s41564-024-01684-z