Cancer BiologybioRxiv
Endothelial Rap1B mediates T-cell exclusion to promote tumor growth -a novel mechanism underlying vascular immunosuppression
G. P. Sharma, R. Kosuru, S. Lakshmikanthan…·M. Chrzanowska
This study identifies EC Rap1B as a key mediator of vascular immunosuppression by promoting T-cell exclusion and tumor growth through regulation of CAMs and NFκB signaling.
DOI 10.1007/s10456-022-09862-5