W. Cui

antiCD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8 T cell cytotoxicity after traumatic brain injury

This study shows that anti-CD49d antibody treatment reduces age-related inflammatory responses and CD8 T cell cytotoxicity after traumatic brain injury in mice.

Directed Micro-Ecology Application System: On-site One-step Fermentation Facilitating Microbial Application through Theoretical and Equipment Innovation

The paper introduces a directed micro-ecology system with an intelligent fermentor that enhances microbial stability and effectiveness across multiple applications.

mTORC2-mediated cell-cell interactions promote BMP4-induced WNT activation and mesoderm differentiation

This study shows mTORC2 is required for BMP4-induced WNT activation and mesoderm differentiation through cell-cell interactions in hESCs.

Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.

Cell therapy with IL-10-producing group 2 innate lymphoid cells suppresses Graft-versus-Host disease

This study demonstrates that IL-10-producing group 2 innate lymphoid cells (ILC210) can suppress Graft-versus-Host Disease (GVHD) in a humanized model without compromising graft-versus-leukemic effects.

MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATION

This study shows that CB2R on microglia drives neuroinflammation in GVHD by promoting T cell activation and neuronal death, and that targeting CB2R reduces inflammation without worsening systemic GVHD.

A murine commensal protozoan relieves Clostridium difficile infection through regulating the arginine metabolism and the host intestinal immune response

This study identifies a murine gut protozoan that alleviates Clostridium difficile infection by modulating arginine metabolism and host immune responses.

Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors

The paper reports the crystal structure of MPXV E12 and identifies potential inhibitors through docking studies.

Structural insights into the allosteric inhibition of P2X4 receptors

This study reports cryo-EM structures of zebrafish P2X4 receptors bound to antagonists, revealing ligand-dependent structural changes that explain subtype-specific allosteric inhibition.

Crystal structure of monkeypox H1 phosphatase, an Antiviral Drug Target

The paper determines the crystal structure of monkeypox H1 phosphatase, revealing its dimeric form and active site, which informs antiviral drug development.

Dysfunction of the Polycomb protein RYBP and of 5-methylcytosine oxidases leads to widespread CpG island hypermethylation and cell transformation

This study shows that dysfunction of RYBP and TET proteins causes CpG island hypermethylation and cell transformation in bronchial cells.

Delineating the transcriptional landscape and clonal diversity of virus- specific CD4 + T cells during chronic viral infection

This study uses scRNA-seq and scTCR-seq to analyze virus-specific CD4+ T cells during chronic LCMV infection, identifying distinct transcriptional states and clonal diversity.

Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

This study identifies 4-vinylanisole as an aggregation pheromone that promotes sexual maturation synchrony in gregarious female locusts through a juvenile hormone/vitellogenin pathway.

Assessment of AI-based Protein Structure Prediction for the NLRP3 Target

This study evaluates AI-based protein structure prediction for NLRP3, showing that AI models can generate reliable structures useful for small-molecule drug discovery.

Endothelial Rap1B mediates T-cell exclusion to promote tumor growth -a novel mechanism underlying vascular immunosuppression

This study identifies EC Rap1B as a key mediator of vascular immunosuppression by promoting T-cell exclusion and tumor growth through regulation of CAMs and NFκB signaling.

Kidney pathology alters cell-clustering in single cell RNA sequencing

The paper shows that kidney injury affects cell clustering in scRNA-Seq by reducing specific cell groups and markers, emphasizing the need for histology screening before analysis.

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

The paper identifies a reservoir of stem-like CD8 T cells in tumor-draining lymph nodes that sustain anti-tumor immunity by maintaining TCF1 expression and resisting terminal differentiation.

Tissue-resident CD4+ T helper cells assist protective respiratory mucosal B and CD8+ T cell memory responses

This study identifies tissue-resident CD4+ T helper (TRH) cells that support local B and CD8+ T cell memory responses in the lung after influenza infection.

An improved comprehensive strategy for deep and quantitative N-glycomics based on optimization of sample preparation, isotope-based data quality control and quantification, new N-glycan libraries and new algorithms

The paper presents an improved strategy for deep N-glycomics with optimized sample prep, isotope-based QC, new libraries, and algorithms, but the manuscript was withdrawn due to incomplete data.

Architecture of the Tuberous Sclerosis Protein Complex

This study uses cryo-EM to determine the structure of the TSCC complex, revealing its architecture and potential mechanisms of Rheb regulation.

The effect of resource dynamics on species packing in diverse ecosystems

The paper examines how resource dynamics influence species packing in ecosystems, showing species can occupy only half of available niches in certain conditions.

The Community Simulator: A Python package for microbial ecology

The paper introduces a Python package for simulating microbial community dynamics, showing improved performance using a new EM algorithm for finding equilibrium states.

A minimal model for microbial biodiversity can reproduce experimentally observed ecological patterns

The paper shows a minimal model can reproduce ecological patterns in microbial communities observed in surveys like EMP and HMP.

The Minimum Environmental Perturbation Principle: A New Perspective on Niche Theory

The paper introduces the Minimum Environmental Perturbation Principle (MEPP) as a framework to analyze ecosystems and ecological invasions by minimizing environmental impact.

Rapidly cycling stem cells regenerate the intestine independent of Lgr5high cells

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

Transcriptional Differences of Peanut (Arachis hypogaea L.) Seeds in the Fresh-harvest, After-ripened and Just-germinated States: insights into regulatory networks of seed dormancy-release and germination

This study identifies transcriptional changes in peanut seeds during dormancy release and germination, revealing key pathways and hormone-related genes involved in these processes.

Diverse communities behave like typical random ecosystems

The paper extends May's theorem by showing that diverse ecosystems reorganize into stable states with random interactions beyond the May threshold.

Available energy fluxes drive a transition in the diversity, stability, and functional structure of microbial communities

This study shows that available energy fluxes drive a transition in microbial community diversity, stability, and function, shifting from resource-limited to preference-driven regimes.

Assessment of gibberellin (GA4+7) mediated changes on grain filling, hormonal behaviour and antioxidants in high-density maize (Zea Mays L.)

This study evaluates the effects of GA4+7 application on maize grain filling, hormone levels, and antioxidants under different treatment methods, finding that 60 mg L-1 GA4+7 improves grain filling and delays leaf senescence.