Author

G. Xin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

A. N. Lane· 2 shared D. A. Scott· 2 shared J. R. Gnanaprakasam· 2 shared J. Yang· 2 shared J. Zhang· 2 shared L. Liu· 2 shared R. Wang· 2 shared S. Kang· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. N. Lane

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

J. Chen, B. Zhao, H. Dong, T. Li, X. Cheng, W. Gong, J. Wang, J. Zhang, G. Xin, Y. Yu, Y. Lei, J. Black, Z. Li, H. Wen

This study shows that inhibiting OGT activates type I interferon-dependent antitumor immunity by enhancing the cGAS-STING pathway through genomic instability.

bioRxiv · Dec 14, 2023Cancer Biology

NuSAP participates in metaphase spindle length control in mammalians

C. Zhang, Y. Wang, M. Sun, G. Xin, B. Yang, Q. Jiang

This study identifies NuSAP's role in regulating metaphase spindle length by controlling microtubule flux and Kif2A localization during mitosis.

bioRxiv · Feb 26, 2023 · PreprintCell Biology

Biphasic response of CD8 T cell to asparagine restriction maximizes its metabolic fitness and antitumoral functionality

J. R. Gnanaprakasam, L. Liu, X. Chen, S. Kang, T. Wang, T. A. Cassel, C. M. Adams, R. M. Higashi, D. A. Scott, G. Xin, J. Yang, A. N. Lane, T. W. Fan, J. Zhang, R. Wang

This study shows that asparagine restriction induces a biphasic response in CD8 T cells, enhancing their metabolic fitness and antitumoral function through ATF4/NRF2-dependent mechanisms.

bioRxiv · Jul 18, 2022 · PreprintImmunology

Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2

O. Rosas Mejia, E. Gloag, J. Li, M. Ruane-Foster, T. A. Claeys, D. Farkas, L. Farkas, G. Xin, R. Robinson

The paper shows Mtb-infected mice are resistant to secondary SARS-CoV-2 infection without affecting Mtb levels, linked to T and B cell expansion in the lungs.

bioRxiv · Nov 9, 2021 · PreprintImmunology

Endothelial Rap1B mediates T-cell exclusion to promote tumor growth -a novel mechanism underlying vascular immunosuppression

G. P. Sharma, R. Kosuru, S. Lakshmikanthan, S. Zheng, Y. Chen, R. Burns, G. Xin, W. Cui, M. Chrzanowska

This study identifies EC Rap1B as a key mediator of vascular immunosuppression by promoting T-cell exclusion and tumor growth through regulation of CAMs and NFκB signaling.

bioRxiv · Nov 3, 2021Cancer Biology

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

X. Chen, B. Sunkel, M. Wang, S. Kang, T. Wang, J. R. Gnanaprakasam, L. Liu, T. A. Cassel, D. A. Scott, A. M. Munoz-Cabello, J. Lopez-Barneo, J. Yang, A. N. Lane, G. Xin, B. Stanton, , R. Wang

This study shows that succinate dehydrogenase/complex II is essential for T cell proliferation and inflammation by regulating metabolic flux and epigenetic modifications.

bioRxiv · Oct 26, 2021Immunology

The mitochondrial deubiquitinase USP30 regulates AKT/mTOR signaling

R. Zhang, J. Krigman, S. Ozgen, H. Luo, Y. Zhao, G. Xin, N. Sun

This study shows Parkin promotes AKT degradation during mitophagy, while USP30 protects AKT, influencing cell apoptosis and USP30's broader physiological roles.

bioRxiv · Oct 25, 2021Pharmacology & Toxicology