G. Seim

Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenasecomplex and impact muscle cell metabolism

This study shows reactive nitrogen species inhibit BCKDC by modifying its E2 subunit lipoic arm, leading to reduced BCAA oxidation and altered energy metabolism in muscle cells.

Asparagine starvation suppresses histone demethylation through iron depletion

This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.