Asparagine starvation suppresses histone demethylation through iron depletion
J. Zhang, J. Jiang, S. Srivastava, S. Liu, G. Seim, M. Zhong, S. Cao, U. Dave, R. Kapur, A. L. Mosley, C. Zhang, J. Wan, J. Fan
This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.
bioRxiv · Aug 14, 2022Cell Biology