S. Deng

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

CRISPR-Cas9/Cas12a Systems for efficient genome editing and large genomic fragment deletions in Aspergillus niger

This paper compares CRISPR-Cas9 and Cas12a systems for genome editing and large fragment deletions in Aspergillus niger, showing Cas12a's higher efficiency with single gRNA and both systems achieving 100% efficiency with two gRNAs.

An AINTEGUMENTA phospho-switch controls bilateral stem cell activity during secondary growth

This paper identifies a phosphorylation mechanism controlled by the ERECTA receptor and auxin signaling that regulates stem cell activity and vascular cell differentiation in plants.

Unveiling the mechanisms of black phosphorus nanosheets-induced viable but non-culturable state in Bacillus tropicus

This study investigates how black phosphorus nanosheets induce a viable but non-culturable state in Bacillus tropicus, revealing suppressed metabolism and respiratory pathways as key mechanisms.

Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer

This study evaluates the biological activity of 60c, a next-generation colchicine-binding site inhibitor, showing improved potency and anti-metastatic effects in triple-negative breast cancer models.

Lac-Phe mediates the anti-obesity effect of metformin

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers

This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.

Ultrasound-Induced Reorientation for Multi-Angle Optical Coherence Tomography

This paper introduces ULTIMA-OCT, a method using ultrasound to reorient samples for multi-angle OCT, improving 3D reconstruction of zebrafish larvae and tumor spheroids.

Logic Gate Activated Lysosome Targeting DNA Nanodevice for Controlled Proteins Degradation

This paper develops a logic-gate activated lysosome targeting DNA nanodevice for controlled protein degradation and modulates T cell-mediated antitumor immunity.

Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex

The paper determines the crystal structure of a Cse4 peptide bound to the Okp1-Ame1 heterodimer in budding yeast, revealing key interactions essential for centromere recognition.

Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies

This study creates a semi-synthetic inhibitor of NatB using coenzyme A and full-length alpha-synuclein, revealing structural and conformational changes upon binding.

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels

The paper identifies CYP4F2 as a human-specific genetic determinant of plasma N-acyl amino acid levels and shows its role in metabolic diversification.

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

Shape-shifting microgel automata controlled by DNA sequence instructions

The paper demonstrates DNA-controlled microgel automata that transform between complex shapes using designed DNA sequences and neural networks.

Galectin-8 is a major ligand of LILRB4 prompting MDSC functions in the tumor microenvironment

This study identifies Galectin-8 as a functional ligand of LILRB4 that promotes MDSC expansion and tumor growth, suggesting its blockade as a potential immunotherapy strategy.

CARD8 negatively regulates NLRP1 inflammasome activation level by interaction with NLRP1

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

A self-blinking DNA probe for 3D superresolution imaging of native chromatin

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

The ITPRIPL1- CD3ϵ axis: a novel immune checkpoint controlling T cells activation

The paper identifies ITPRIPL1 as a novel immune checkpoint that inhibits T cell activation by interacting with CD3ε, suggesting it as a therapeutic target for PD-1/PD-L1 negative tumors.

JAK-STAT Signaling Enables Lineage Plasticity-driven AR Targeted Therapy Resistance

The paper identifies JAK-STAT signaling as a key driver of lineage plasticity-driven resistance to AR targeted therapy in prostate cancer using integrated transcriptomic and scRNA-Seq analysis.

Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.

Tumor-Cell Invasion Initiates at Invasion Hotspots, an Epithelial Tissue-Intrinsic Microenvironment

The paper shows that tumor-cell invasion in Drosophila wing imaginal epithelia starts at specific invasion hotspots where JNK signaling and MMP1 activity drive basal extrusion and basement membrane destruction.

Differences in IgG antibody responses following BNT162b2 and mRNA-1273 Vaccines

This study compares IgG antibody responses to BNT162b2 and mRNA-1273 vaccines, finding higher and earlier titers with mRNA-1273, possibly due to higher S-protein dosage.

Molecular mechanism of N-terminal acetylation by the ternary NatC complex

The paper reports the Cryo-EM structure of S. pombe NatC complex and identifies IP6 as a stabilizer, revealing substrate specificity overlaps with NatE.

Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D

This study designs and characterizes potent bisubstrate inhibitors for NatD, showing high selectivity and revealing the enzyme's ordered Bi-Bi mechanism through crystal structures.

Pixelwise H-score: a novel digital image analysis based-metric to quantify membrane biomarker expression from immunohistochemistry images

This paper introduces a new digital image analysis metric, the pixelwise H-score, to quantify membrane biomarker expression in IHC images, showing it is comparable or better than existing methods.

Tet2 Controls Beta cells Responses to Inflammation in Type 1 Diabetes

This study identifies Tet2's role in regulating β cell responses to inflammation in Type 1 Diabetes, showing its protective effects against immune-mediated destruction.

SARS-CoV-2 spike D614G variant exhibits highly efficient replication and transmission in hamsters

This study compares SARS-CoV-2 strains in hamsters, finding that the D614G spike variant shows higher replication and transmission efficiency.

Pathogenicity, immunogenicity, and protective ability of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein

This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.

Pan-genome analyses of peach and its wild relatives provide insights into the genetics of disease resistance and species adaptation

The paper performs pan-genome analysis of peach and its wild relatives to identify genetic variations related to disease resistance and high-altitude adaptation.