Inheritance of old mitochondria controls early CD8+ T cell fate commitment and is regulated by autophagy
M. Borsa, A. V. Lechuga-Vieco, A. H. Kayvanjoo, Y. Yazicioglu, E. B. Compeer, F. C. Richter, H. Bui, M. L. Dustin, P. Katajisto, A. K. Simon
This study shows that autophagy regulates asymmetric inheritance of old mitochondria in CD8+ T cells, which influences their metabolic state and memory potential.
bioRxiv · Jan 29, 2024 · PreprintCell Biology