H. Chun

Myospreader improves gene editing in skeletal muscle by myonuclear propagation

Myospreader enhances CRISPR/Cas9 gene editing in skeletal muscle by promoting myonuclear propagation and improving therapeutic efficacy in mouse models.

Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size.

The paper shows that competition between hematopoietic stem cells and progenitors regulates HSC compartment size through mSCF availability.

Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude

The paper uses optical tools to show that RhoA activation levels determine distinct cellular responses, with low levels causing focal adhesion disassembly and high levels causing both growth and disassembly.

Single-cell analysis of a mutant library generated using CRISPR-guided deaminase

The paper develops a CRISPR-based platform combining deaminase and scRNA-seq to introduce and assess substitution mutations, enabling high-throughput analysis of mutation-associated transcriptional effects.