Author

L. Ning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Physiology· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Herrlich· 3 shared E. Kefaloyianni· 3 shared M. Lin· 3 shared M. Westberg· 3 shared Y. Su· 3 shared A. Arthanarisami· 2 shared D. Kreisel· 2 shared W. Li· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPhysiology

A. Herrlich

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Acute kidney injury triggers hypoxemia by inducing intravascular neutrophil retention that reduces lung capillary blood flow

Y. Komaru, L. Ning, C. Lama, A. Suresh, E. Kefaloyianni, M. J. Miller, S. Kawana, H. M. Shepherd, W. Li, D. Kreisel, A. Herrlich

This study identifies that acute kidney injury causes hypoxemia through intravascular neutrophil retention in lung capillaries, reducing blood flow without lung edema.

bioRxiv · Feb 27, 2024Physiology

Adaptive immunity: from CRISPR to CRIHSP?

Z. Niu, Y. Wang, B. Xu, X. Jin, L. Ning, Y. Hao, Y. Yan, M. Wang, W. Zhu, L. Zhi, C. Guo

The paper identifies CRIHSP structures in human adaptive immunity genes, showing their association with genomic instability and recombination.

bioRxiv · Sep 25, 2023 · PreprintImmunology

Design of SARS-CoV-2 protease inhibitors with improved affinity and reduced sensitivity to mutations

M. Westberg, Y. Su, X. Zou, P. Huang, A. Rustagi, J. Garhyan, P. B. Patel, D. Fernandez, Y. Wu, L. Ning, A. Beck, M. Karim, C. Hao, P. Saenkham-Huntsinger, V. Tat, , M. Z. Lin

This study designs a SARS-CoV-2 protease inhibitor with improved affinity and reduced mutation sensitivity compared to existing drugs.

bioRxiv · Jul 19, 2023 · PreprintMicrobiology

Acute kidney injury-induced circulating TNFR1/2 elevations correlate with persistent kidney injury and progression to fibrosis

A. Arthanarisami, Y. Komaru, C. Katsouridi, J. Schumacher, D. K. Verges, L. Ning, M. M. Abdelmageed, A. Herrlich, E. Kefaloyianni

This study shows that acute kidney injury (AKI) increases circulating TNFR1/2 levels, which correlate with kidney injury severity and progression to fibrosis, particularly through extracellular vesicle-bound forms.

bioRxiv · Apr 3, 2023Physiology

Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain

Y. Wu, J. Walker, L. Ning, M. Westberg, M. Monje, T. Kirkland, M. Lin, Y. Su

This paper introduces KiMBIs, bioluminescent indicators that enable non-invasive imaging of kinase inhibitor activity in the brain, identifying temuterkib as a promising brain-active ERK inhibitor.

bioRxiv · Dec 30, 2022Pharmacology & Toxicology

Methacrylate-Modified Gold Nanoparticles Enable Non-Invasive Monitoring of Photocrosslinked Hydrogel Scaffolds

L. Li, C. J. Gil, T. A. Finamore, C. J. Evans, M. L. Tomov, L. Ning, A. Theus, G. Kabboul, V. Serpooshan, R. K. Roeder

This study develops methacrylate-modified gold nanoparticles (AuMA NPs) to enable non-invasive monitoring of hydrogel scaffolds via X-ray micro-CT.

bioRxiv · Jan 26, 2022 · PreprintBioengineering

Circulating osteopontin released by injured kidneys causes pulmonary inflammation and edema

F. Z. Khamissi, L. Ning, E. Kefaloyianni, H. Dun, A. Arthanarisami, A. Keller, J. J. Atkinson, W. Li, B. W. Wong, S. Dietmann, K. Lavine, D. Kreisel, A. Herrlich

This study identifies osteopontin (OPN) released by injured kidneys as a mediator of acute lung injury, showing its role in causing pulmonary inflammation and edema.

bioRxiv · Jul 20, 2021 · PreprintCell Biology

Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude

J. Ju, H. N. Lee, L. Ning, H. Ryu, X. X. Zhou, H. Chun, Y. W. Lee, A. I. Lee-Richerson, C. Jeong, M. Lin, J. Seong

The paper uses optical tools to show that RhoA activation levels determine distinct cellular responses, with low levels causing focal adhesion disassembly and high levels causing both growth and disassembly.

bioRxiv · Feb 5, 2021Bioengineering

Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases

M. Westberg, Y. Su, X. Zou, L. Ning, B. Hurst, B. Tarbet, M. Lin

The paper designs a new class of protease inhibitors targeting coronavirus Mpro, identifying ML1000 as a potent inhibitor with low-nanomolar affinity and antiviral activity.

bioRxiv · Sep 15, 2020Biochemistry