GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
G. Austin, A. I. Oqua, L. ElEid, M. Zhu, Y. Manchanda, P. Peres, H. Coyle, Y. Poliakova, K. Bouzakri, A. Montoya, D. J. Withers, M. Solimena, B. Jones, S. J. Millership, S. Burgold, , A. Tomas
This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.
bioRxiv · Apr 28, 2024Cell Biology