A. Muller

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

Molecular Dynamics Study of α-Synuclein Domain Deletion Mutant Monomers

This study uses molecular dynamics simulations to analyze how domain deletions in α-synuclein affect protein structure and interactions with lipid membranes.

Comprehensive chromatome profiling identifies metabolic enzymes on chromatin in healthy and cancer cells

The paper identifies widespread metabolic enzyme localization on chromatin in healthy and cancer cells, showing tissue-specific abundance and non-canonical roles in DNA damage and repair.

Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

This study shows that SARS-CoV-2 variants differ in syncytia formation, which affects host chromatin accessibility, cellular senescence, and inflammation via TP53.

High-efficiency base editing for Stargardt disease in mice, non-human primates, and human retina tissue

This study develops a base-editing strategy to correct the ABCA4 mutation in mice, non-human primates, and human retinal tissue, achieving high editing rates in vivo.

Maternal diet and gut microbiome composition modulate early life immune development

This study shows that maternal diet and gut microbiome composition affect early immune development in offspring by altering microbial colonization and immune gene expression.

Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts

This study characterizes the tumor microenvironment in glioblastoma patient-derived xenografts and patient tumors, revealing phenotypic heterogeneity in microglia and their functional adaptations.

A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma

This study identifies genes and pathways involved in senescence escape in NRAS mutant melanoma using multi-omics approaches.

Accuracy of a markerless motion capture system for balance related quantities

This study evaluates a markerless motion capture system for balance-related quantities, finding acceptable accuracy for most applications but larger errors in dynamic movements.

Description, Development and Dissemination of Two Consistent Marker-based and Markerless Multibody Models

This paper develops and describes a whole-body marker-based model and a markerless multibody model for human movement analysis, and compares their performance in a static T-pose task.

Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine

This study shows that glioma PDOX models accurately represent patient tumors and can predict treatment responses in personalized medicine.

Protein Interaction Screen on Peptide Matrix (PRISMA) reveals interaction footprints and the PTM-dependent interactome of intrinsically disordered C/EBPβ

The paper uses PRISMA to map C/EBPβ's PTM-dependent interactome, revealing interaction footprints and functional links to chromatin and RNA processing.