Author

H. Endou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. F. Wempe· 2 shared A. Clarke· 1 shared A. Filer· 1 shared A. M. Thomas· 1 shared C. Jin· 1 shared D. Windell· 1 shared E. Marin· 1 shared E. Pantazi· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

M. F. Wempe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis

J. Ogbechi, H. L. Wright, S. Balint, L. Topping, K. Zec, I.-S. Huang, E. Pantazi, M. Swart, D. Windell, E. Marin, M. F. Wempe, H. Endou, A. M. Thomas, A. Filer, T. W. Stone, , R. Williams

This study shows LAT1 is critical for T cell activation in rheumatoid arthritis and identifies it as a therapeutic target, with a LAT1 inhibitor effective in mouse models.

bioRxiv · Dec 20, 2022 · PreprintImmunology

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

Y. Lee, P. Wiriyasermkul, C. Jin, L. Quan, R. Ohgaki, S. Okuda, T. Kusakizako, T. Nishizawa, K. Oda, R. Ishitani, T. Yokoyama, T. Nakane, M. Shirouzu, H. Endou, S. Nagamori, , O. Nureki

This paper reports the cryo-EM structure of the human LAT1-CD98hc heterodimer, revealing its architecture and interactions, and maps disease mutations to explain congenital disorders.

bioRxiv · Mar 14, 2019Biochemistry

Pharmacological inhibition of the amino-acid transporter LAT1 demonstrates in vitro anti-neoplastic activity towards medulloblastoma

Y. Cormerais, M. Pagnuzzi-Boncompagni, S. Schrötter, S. Giuliano, E. Tambutte, H. Endou, M. F. Wempe, G. Pages, J. Pouyssegur, V. Picco

This study shows that JPH203, a LAT1 inhibitor, effectively reduces medulloblastoma cell proliferation and survival without harming normal cells.

bioRxiv · Jan 8, 2019Cancer Biology