Author

H. Erfle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

J. Beneke· 2 shared A. Hiemisch· 1 shared A. L. Vera-Guapi· 1 shared A. Mueller· 1 shared B. Bruegger· 1 shared B. Cerikan· 1 shared B. Eismann· 1 shared C. Conrad· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

J. Beneke

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin/CBP inhibitor PRI-724 as a potent antiviral

M. A. Kelch, A. L. Vera-Guapi, T. Beder, M. Oswald, A. Hiemisch, N. Beil, P. Wajda, S. Ciesek, H. Erfle, T. Toptan, R. König

This paper uses machine learning on perturbation screens to identify PRI-724 as a potent antiviral targeting β-catenin/CBP, effective against multiple coronaviruses and influenza.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation

K. Tabata, V. Prasad, D. Paul, J.-Y. Lee, M.-T. Pham, W.-I. Twu, C. J. Neufeldt, M. Cortese, B. Cerikan, C. S. Tran, C. Luechtenborg, P. Vkovski, K. Hoermann, A. Mueller, C. Zitzmann, , R. Bartenschlager

This study identifies phosphatidic acid as critical for double membrane vesicle formation in HCV and SARS-CoV-2 replication, suggesting host-targeted PA synthesis inhibition as a therapeutic strategy.

bioRxiv · May 10, 2021Microbiology

Automated screening by 3D light-sheet microscopy with high spatial and temporal resolution reveals mitotic phenotypes

B. Eismann, T. G. Krieger, J. Beneke, R. Bulkescher, L. Adam, H. Erfle, C. Herrmann, R. Eils, C. Conrad

The paper presents a workflow using 3D light-sheet microscopy and automated image processing to screen mitotic phenotypes in 3D cell cultures with high throughput.

bioRxiv · Jan 20, 2020Cell Biology