Author

B. Cerikan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Cortese· 6 shared R. Bartenschlager· 6 shared C. J. Neufeldt· 5 shared J.-Y. Lee· 2 shared V. Prasad· 2 shared A. Andrejeva· 1 shared A. Castello· 1 shared A. I. Järvelin· 1 shared

Activity by Year

2020-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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6 shared papersMicrobiology

M. Cortese

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation

K. Tabata, V. Prasad, D. Paul, J.-Y. Lee, M.-T. Pham, W.-I. Twu, C. J. Neufeldt, M. Cortese, B. Cerikan, C. S. Tran, C. Luechtenborg, P. Vkovski, K. Hoermann, A. Mueller, C. Zitzmann, , R. Bartenschlager

This study identifies phosphatidic acid as critical for double membrane vesicle formation in HCV and SARS-CoV-2 replication, suggesting host-targeted PA synthesis inhibition as a therapeutic strategy.

bioRxiv · May 10, 2021Microbiology

Global analysis of protein-RNA interactions in SARS-CoV-2 infected cells reveals key regulators of infection

W. Kamel, M. Noerenberg, B. Cerikan, H. Chen, A. I. Järvelin, M. Kammoun, J. Lee, N. Shuai, M. Garcia-Moreno, A. Andrejeva, M. J. Deery, C. J. Neufeldt, M. Cortese, M. L. Knight, K. S. Lilley, , A. Castello

The paper identifies key host and viral RNA-binding proteins involved in SARS-CoV-2 infection and shows that drugs targeting these proteins can inhibit infection.

bioRxiv · Nov 25, 2020Microbiology

Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19

K. Steuten, H. Kim, J. C. Widen, B. M. Babin, O. Onguka, S. Lovell, O. Bolgi, B. Cerikan, M. Cortese, R. K. Muir, J. M. Bennett, R. Geiss-Friedlander, C. Peters, R. Bartenschlager, M. Bogyo

This study evaluates compounds targeting SARS-CoV-2 proteases Mpro and PLpro, finding limited efficacy for Mpro due to off-target inhibition of host cathepsins and no viable hits for PLpro.

bioRxiv · Nov 21, 2020Microbiology

A versatile reporter system to monitor virus infected cells and its application to dengue virus and SARS-CoV-2

F. Pahmeier, C. J. Neufeldt, B. Cerikan, V. Prasad, C. Pape, V. Laketa, A. Ruggieri, R. Bartenschlager, M. Cortese

This paper introduces a versatile reporter system that detects virus-infected cells by using protease activity and applies it to dengue virus and SARS-CoV-2.

bioRxiv · Aug 31, 2020Microbiology

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

C. J. Neufeldt, B. Cerikan, M. Cortese, J. Frankish, J.-Y. Lee, A. Plociennikowska, F. Heigwer, S. Joecks, S. S. Burkart, D. Y. Zander, M. Gendarme, B. El Debs, N. Halama, U. Merle, M. Boutros, , R. Bartenschlager

This study shows SARS-CoV-2 triggers a pro-inflammatory cytokine response via cGAS-STING and NF-κB in epithelial cells, which may contribute to severe disease.

bioRxiv · Jul 21, 2020Microbiology

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

S. Klein, M. Cortese, S. L. Winter, M. Wachsmuth-Melm, C. J. Neufeldt, B. Cerikan, M. L. Stanifer, S. Boulant, R. Bartenschlager, P. Chlanda

This study uses in situ cryo-electron tomography to visualize SARS-CoV-2 replication compartments and virion structure, revealing RNA filament organization and vRNP packaging mechanisms.

bioRxiv · Jun 23, 2020Microbiology