Author

H. Hubner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

P. Gmeiner· 2 shared A. A. Inoue· 1 shared A. Allikalt· 1 shared A. Basbaum· 1 shared A. Ullrich· 1 shared B. Bottcher· 1 shared B. K. Shoichet· 1 shared B. Kobilka· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPharmacology & Toxicology

P. Gmeiner

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Discovery of a functionally selective serotonin 5-HT1A receptor agonist for the treatment of pain

A. Ullrich, J. Schneider, J. M. Braz, E. Neu, N. Staffen, M. Stanek, J. Blahova, T. Hove, T. Albert, A. Allikalt, S. Lober, K. Bhardwaj, S. Rodriguez-Rosado, E. A. Fink, T. Rasmussen, , P. Gmeiner

The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.

bioRxiv · Sep 11, 2023 · PreprintPharmacology & Toxicology

An allosteric ligand stabilizes distinct conformations in the M2 muscarinic acetylcholine receptor

J. Xu, H. Hubner, Y. Hu, X. Niu, P. Gmeiner, C. Jin, B. Kobilka

This study uses NMR to show that the PAM LY2119620 changes the structure and dynamics of M2R in both extracellular and G-protein coupling domains, stabilizing distinct conformations not seen with orthosteric agonists.

bioRxiv · Feb 14, 2021 · PreprintBiophysics