Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
J. Zhao, M. Elgeti, E. O'Brien…·C. Chen
The paper uses biophysical techniques to show how ligand-induced conformational changes in the μ-opioid receptor affect its signaling efficacy.
H. Wang, F. Hetzer, W. Huang…·P. Gmeiner
The paper reports cryoEM structures of the μ-opioid receptor bound to biased agonists PZM21 and FH210, revealing structural basis for reduced β-arrestin recruitment and guiding development of safer analgesics.
J. Xu, H. Hubner, Y. Hu…·B. Kobilka
This study uses NMR to show that the PAM LY2119620 changes the structure and dynamics of M2R in both extracellular and G-protein coupling domains, stabilizing distinct conformations not seen with orthosteric agonists.