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12 papers
Recent·Most cited
Q. Qu, Y. Chen, Y. Wang, S. Long, W. Wang, H.-Y. Yang, M. Li, X. Tian, X. Wei, Y.-H. Liu, S. Xu, C. Zhang, M. Zhu, S. M. Lam, J. Wu, , S.-C. Lin
This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.
bioRxiv · Dec 7, 2023 · PreprintPhysiology
Q. Qu, Y. Chen, Y. Wang, S. Long, W. Wang, H.-Y. Yang, J. Wu, M. Li, X. Tian, X. Wei, Y.-H. Liu, S. Xu, C. Yang, Z. Wu, X. Huang, , Y. Yu
This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.
bioRxiv · Dec 7, 2023 · PreprintPhysiology
Y. Wang, P. Zhang, Y. Chao, Z. Zhu, C. Yang, Z. Zhou, Y. Li, Y. Long, Y. Liu, D. Li, S. Wang, Q. Qu
This study presents cryo-EM structures of VMAT2 bound to substrates and inhibitors, revealing conformational changes and mechanisms of ligand recognition and inhibition.
bioRxiv · Oct 27, 2023 · PreprintBiophysics
M. Wallis, Q. Qu, M. Krawczyk, D. Skowronska-Krawczyk
This study investigates the evolutionary changes in the regulatory region of the POU1F1 gene, identifying conserved enhancer elements and alternative promoters across vertebrates.
bioRxiv · Jul 26, 2023 · PreprintEvolutionary Biology
M. Li, Y. Wang, X. Wei, W.-F. Cai, M. Zhu, L. Yao, Y. Wang, Y.-H. Liu, J. Wu, J. Xiong, X. Tian, Q. Qu, R. Xie, X. Li, S. Chen, , S.-C. Lin
This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.
bioRxiv · Jul 20, 2023 · PreprintCell Biology
C. Shi, S. Chen, H. Liu, S. Li, Y. Wang, R. Pan, X. Wu, X. Li, J. Li, C. Xing, X. Liu, Y. Wang, Q. Qu, G. Li
The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.
bioRxiv · Jun 11, 2023Evolutionary Biology
H. Li, J. He, J. Liang, Y. Liang, W. Zheng, Q. Qu, F. Guo
The paper compares co-evolutionary lineages of gut microbes in wild primates and humans, revealing opposing health implications of specific microbial traits.
bioRxiv · May 30, 2023 · PreprintMicrobiology
H. Wang, F. Hetzer, W. Huang, Q. Qu, J. Meyerowitz, J. Kaindl, H. Huebner, G. Skiniotis, B. Kobilka, P. Gmeiner
The paper reports cryoEM structures of the μ-opioid receptor bound to biased agonists PZM21 and FH210, revealing structural basis for reduced β-arrestin recruitment and guiding development of safer analgesics.
bioRxiv · Mar 22, 2022Pharmacology & Toxicology
A. Zheng, X. Wang, Y. Zhang, D. Liang, F. Yuan, Y. Yan, Z. Wang, P. Liu, Q. Qu, X. Zhang
This study identifies key molecular factors determining mosquito-borne flavivirus host tropism by comparing insect-specific and dual-host flaviviruses.
bioRxiv · Dec 21, 2021 · PreprintMicrobiology
Q. Qu, W. Huang, D. Aydin, J. M. Paggi, A. B. Seven, H. Wang, S. Chakraborty, T. Che, J. F. DiBerto, M. J. Robertson, A. Inoue, B. L. Roth, S. Majumdar, R. O. Dror, B. K. Kobilka, G. Skiniotis
This study compares the structural and signaling differences between two μOR agonists, lofentanil and mitragynine pseudoindoxyl, revealing how their distinct binding modes lead to different G protein and β-arrestin activation profiles.
bioRxiv · Dec 7, 2021 · PreprintBiophysics
Z. Cai, J. Dong, X. Zhang, Q. Qu, F. Wu, L. Cao, S. Li, Z. Wang, D. Zhou, J. Luo, X. Yu
The paper investigates photosynthesis-related gene expression in albino Artocarpus heterophyllus seedlings, finding down-regulated genes in pigment synthesis and photosynthesis pathways.
bioRxiv · Oct 20, 2020 · PreprintPhysiology
S. Gao, W. C. Valinsky, N. C. On, P. R. Houlihan, Q. Qu, L. Liu, P. Xiaojing, D. E. Clapham, N. Yan
The paper presents cryo-EM structures of NaChBac in nanodiscs and its complex with HuwenToxin IV, revealing toxin docking details and enabling studies of GMTs on Nav channels.
bioRxiv · Apr 16, 2020Biophysics