Author

J. Meyerowitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

C. Willberg· 2 shared E. Hopkins· 2 shared G. Skiniotis· 2 shared H. Brown· 2 shared J. Fox· 2 shared J. Frater· 2 shared M. Pace· 2 shared N. Nwokolo· 2 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

C. Willberg

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Author profile →

4 papers

Recent·Most cited

Structure-based discovery of positive allosteric modulators for the calcium sensing receptor

F. Liu, C.-G. Wu, C.-L. Tu, I. Glenn, J. Meyerowitz, A. L. Kaplan, J. Lyu, Z. Cheng, O. O. Tarkhanova, Y. S. Moroz, J. J. Irwin, W. Chang, B. K. Shoichet, G. Skiniotis

The paper uses structure-based virtual screening to identify novel CaSR PAMs with higher potency and reduced side effects compared to existing drugs.

bioRxiv · Dec 27, 2023 · PreprintBiophysics

Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists

H. Wang, F. Hetzer, W. Huang, Q. Qu, J. Meyerowitz, J. Kaindl, H. Huebner, G. Skiniotis, B. Kobilka, P. Gmeiner

The paper reports cryoEM structures of the μ-opioid receptor bound to biased agonists PZM21 and FH210, revealing structural basis for reduced β-arrestin recruitment and guiding development of safer analgesics.

bioRxiv · Mar 22, 2022Pharmacology & Toxicology

HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion

G. E. Martin, M. Pace, F. Shearer, E. Zilber, J. Hurst, J. Meyerowitz, J. P. Thornhill, J. Lwanga, H. Brown, N. Robinson, E. Hopkins, N. Olejniczak, N. Nwokolo, J. Fox, S. Fidler, , CHERUB investigators

This study finds that pre-ART HIV DNA levels predict reservoir size one year after treatment initiation during primary HIV infection, linked to CD8 T cell activation and memory expansion.

bioRxiv · Mar 17, 2019Immunology

Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early in blood and tissue

G. Martin, M. Pace, J. Thornhill, C. Phetsouphanh, J. Meyerowitz, M. Gossez, E. Hopkins, H. Brown, N. Robinson, N. Olejniczak, G. Ramjee, P. Kaleebu, K. Porter, C. Willberg, P. Klenerman, , J. Frater

The paper shows HIV DNA enrichment in CD32+ CD4 T cells early in infection but finds no correlation with rebound viraemia or HIV DNA levels.

bioRxiv · Jul 27, 2017Immunology