Author

H. Imamura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 2 Cell Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 7 Research Focus:differential expression· 5 Organism:mouse· 4 Organism:human· 3 Assay:whole-genome sequencing· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

I. Maes· 4 shared J.-C. Dujardin· 4 shared M. A. Domagalska· 4 shared J. A. Cotton· 3 shared M. Berriman· 3 shared M. Jara· 3 shared M. Sanders· 3 shared E. D'Haenens· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

I. Maes

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Author profile →

11 papers

Recent·Most cited

Mechanistic modeling of amyloid oligomer and protofibril formation

K. Yuzu, H. Imamura, T. Nozaki, Y. Fujii, S. M. M. Badawy, K. Morishima, A. Okuda, R. Inoue, M. Sugiyama, E. Chatani

This study establishes a mechanistic model of amyloid oligomer and protofibril formation in bovine insulin using light scattering and kinetic analysis, revealing end-to-end association as the rate-limiting step.

bioRxiv · Sep 2, 2023 · PreprintBiophysics

Long-term hematopoietic stem cells trigger quiescence in Leishmania parasites

L. Dirkx, S. Van Acker, Y. Nicolaes, J. L. R. Cunha, R. Ahmad, B. Caljon, H. Imamura, D. G. Ebo, D. Jeffares, Y. G.-J. Sterckx, L. Maes, S. Hendrickx, G. Caljon

This study shows that Leishmania parasites enter quiescence after 4-6 divisions in hematopoietic stem cells, enabling drug resistance and increased infectivity.

bioRxiv · Aug 23, 2023 · PreprintMicrobiology

Getting Smaller by Denaturation: Acid-Induced Compaction of Antibodies

H. Imamura, A. Ooishi, S. Honda

This study shows that acid denaturation of IgG1 antibodies leads to compaction, reducing their size and suggesting non-canonical structures may have biological significance.

bioRxiv · Sep 19, 2022Biophysics

Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs

P. Chiaranunt, K. Burrows, L. Ngai, E. Y. Cao, S. L. Tai, H. Hamidzada, A. Wong, M. Kuypers, T. Despot, A. Momen, S. M. Lim, T. Mallevaey, T. Conway, H. Imamura, S. Epelman, A. Mortha

The paper identifies a microbial energy metabolism-driven niche in tertiary lymphoid organs that supports intestinal macrophage development via CSF2 and ILC3 activity.

bioRxiv · Mar 23, 2022 · PreprintImmunology

High and stable ATP levels prevent aberrant intracellular protein aggregation

M. Takaine, H. Imamura, S. Yoshida

This study shows that maintaining high and stable ATP levels prevents protein aggregation by showing that AMPK and ADK prevent ATP depletion and cytotoxic protein accumulation in yeast.

bioRxiv · Feb 16, 2021Cell Biology

Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compound

A. Hefnawy, G. Negreira, M. Jara, J. A. Cotton, I. Maes, E. D'Haenens, H. Imamura, B. Cuypers, P. Monsieurs, C. Mouchtoglou, H. De Winter, M. Berriman, M. Sanders, J. Martin, G. De Muylder, , M. A. Domagalska

This study experimentally selects resistance to a novel anti-leishmanial compound in Leishmania donovani and identifies mutations in the dynamin-1-like protein as a key mechanism of resistance.

bioRxiv · Jan 5, 2021Microbiology

Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

H. Imamura, S. Sakamoto, T. Yoshida, Y. Matsui, S. Penuela, D. Laird, S. Mizukami, K. Kikuchi, A. Kakizuka

The paper develops FRET biosensors to show that caspase-3 activation initiates a programmed loss of ATP in apoptotic cells via pannexin-1 cleavage, which arrests metabolic activity.

bioRxiv · Aug 14, 2020Cell Biology

Visualizing ATP Dynamics in Live Mice

N. Koitabashi, R. Ogasawara, R. Yasui, Y. Sugiura, H. Matsuda, S. Nonaka, T. Izumi, M. Kurabayashi, M. Suematsu, M. Yanagita, H. Imamura, M. Yamamoto

The paper develops a transgenic mouse model with GO-ATeam to measure ATP dynamics in real-time across multiple organs and conditions, providing insights into ATP's role in physiology and disease.

bioRxiv · Jun 10, 2020 · PreprintPhysiology

Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level

H. Imamura, M. Jara, P. Monsieurs, M. Sanders, I. Maes, M. Vanaerschot, M. Berriman, J. A. Cotton, J.-C. Dujardin, M. A. Domagalska

The paper evaluates WGA methods for Leishmania single-cell genomics, finding PicoPlex better for aneuploidy and RepliG for SNPs, and detects aneuploidy mosaicism in L. braziliensis.

bioRxiv · Feb 20, 2020Microbiology

Tracking of quiescence in Leishmania by quantifying the expression of GFP in the ribosomal DNA locus

M. Jara, I. Maes, H. Imamura, M. A. Domagalska, J.-C. Dujardin, J. Arevalo

The paper develops a biosensor to track quiescence in Leishmania by quantifying GFP expression from the ribosomal DNA locus, showing it correlates with replication state and is reversible.

Scientific Reports · Dec 12, 2019Peer-reviewedMicrobiology

Genomes of intracellular Leishmania parasites directly sequenced from patients

M. A. Domagalska, H. Imamura, M. Sanders, F. Van den Broeck, N. R. Bhattarai, M. Vanaerschot, I. Maes, E. D'Haenens, K. Rai, S. Rijal, M. Berriman, J. A. Cotton, J.-C. Dujardin

This paper develops a method to directly sequence Leishmania genomes from clinical samples, revealing genomic differences between intracellular parasites and cultured isolates.

bioRxiv · Sep 26, 2019Microbiology