Cancer BiologybioRxiv
Paradoxical activation of oncogenic signaling as a cancer treatment strategy
M. H. Dias, A. Friskes, S. Wang…·R. Bernards
This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.
DOI 10.1158/2159-8290.cd-23-0216