R. Bernards

Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability

This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.

A fluorescence-based sensor screen identifies MED12 as a potential microsatellite instability regulator in colon cancer

PP2A inhibition instructs spliceosome phosphorylation to create splicing vulnerability in colon adenocarcinoma

The paper shows that PP2A inhibition in colon cancer alters splicing patterns, leading to genomic instability and potential improvements in immune therapy responses.

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.

A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF(V600E) colorectal tumors

This study identifies a SRC-relayed COX2-inflammatory program that drives resistance to BRAF/MEK/EGFR therapies in BRAFV600E colorectal tumors and shows that co-targeting COX2 improves therapeutic outcomes.

Genetic and compound screens uncover factors modulating cancer cell response to indisulam

This study identifies genetic and compound factors that modulate cancer cell response to the drug indisulam, revealing therapeutic strategies for its clinical reuse.

Combined SHP2 and ERK inhibition for the treatment of KRAS-driven Pancreatic Ductal Adenocarcinoma

This paper investigates the combination of SHP2 and ERK inhibition as a treatment for KRAS-driven pancreatic ductal adenocarcinoma, showing synergistic anticancer effects and tumor regression in mouse models.

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

The paper identifies that combining indisulam with palbociclib enhances senescence in cancer cells by inhibiting CDK2 kinase activity.

Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

This study identifies ELOF1 as a factor that promotes transcription-coupled repair and prevents genome instability by modulating transcription and recruiting repair factors.

Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant

The paper identifies frequent allelic expression imbalance of PIK3CA mutations in breast cancer and links it to poor prognosis.

Multiple Low Dose therapy: an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours

This paper shows that using multiple low doses of drugs targeting different components of a signaling pathway can effectively treat EGFR inhibitor-resistant NSCLC without resistance development.