K. Susztak

This study shows HIV Vpr reduces DCT1-type renal tubules in mice, leading to salt wasting via apoptosis dysregulation of Slc12a3+ Pvalb+ cells.

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

This study shows that overexpressing Cpt1a in renal tubular epithelial cells reduces fibrosis by restoring mitochondrial function and bioenergetics in CKD models and human patients.

The paper identifies a unique adipocyte population in bone marrow, MERAs, that regulate bone and vessel homeostasis through single-cell transcriptomics in mice.

This study shows that loss of ELK1 leads to age-related fibrosis in the lung and liver but not heart or kidneys, and links reduced ELK1 to cigarette smoke exposure.

This study identifies Jag1/Notch2 as a key driver of kidney fibrosis through Tfam-mediated metabolic reprogramming in mouse models.

The paper uses single-cell RNA sequencing to identify novel kidney cell types and Notch-mediated plasticity in collecting duct cells, which is defective in chronic kidney disease.