Author

A. Karsan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 3

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Research Focus:cell type annotation· 5 Organism:human· 5 Approach:experimental assay· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

G. Cole· 2 shared J. Gsponer· 2 shared J. Parker· 2 shared J. Wang· 2 shared N. Cashman· 2 shared P. F. Lange· 2 shared T. Mayor· 2 shared T. R. Docking· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

G. Cole

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

C. Molzahn, E. Kuechler, L. Nierves, G. Cole, J. Wang, N. Cashman, A. Karsan, P. F. Lange, J. Gsponer, T. Mayor

The paper analyzes protein levels and solubility in brain regions of aged mice, revealing age-related changes in proteostasis and inflammation markers.

bioRxiv · Feb 28, 2024 · PreprintCell Biology

The spatially resolved tumor microenvironment predicts treatment outcome in relapsed/refractory Hodgkin lymphoma

T. Aoki, A. Jiang, A. Xu, Y. Yin, A. Gamboa, K. Milne, K. Takata, T. Miyata-Takata, S. Wu, M. Warren, C. Strong, T. Goodyear, K. Morris, L. C. Chong, M. Hav, , C. Steidl

The paper develops a prognostic model using spatially resolved tumor microenvironment features to predict treatment outcomes in relapsed/refractory Hodgkin lymphoma.

bioRxiv · May 19, 2023Cancer Biology

Shift of the insoluble content of the proteome in aging mouse brain

C. M. Molzahn, E. R. Kuechler, I. Zemlyankina, L. Nieves, T. Ali, G. Cole, J. Wang, R. F. Albu, M. Zhu, N. Cashman, S. Gilch, A. Karsan, P. F. Lange, J. Gsponer, T. Mayor

This study identifies age-related changes in the insoluble proteome of mouse brains, showing a shift in protein characteristics associated with proteostasis decline.

bioRxiv · Dec 13, 2022Cell Biology

Targeting BET Proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML

C. Letson, M. E. Balasis, H. Newman, M. Binder, A. Vedder, F. Kinose, M. Ball, T. Kruer, A. Quintana, T. L. Lasho, C. M. Finke, L. L. Almada, J. M. Grants, G. Zhang, M. E. Fernandez-Zapico, , E. Padron

This study identifies PIM inhibitors as synergistic with BET inhibitors in myeloid leukemia, showing miR-33a downregulation drives PIM1 upregulation and GM-CSF hypersensitivity as a biomarker for combination therapy.

bioRxiv · Nov 1, 2022Cancer Biology

Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of the mitochondrial LONP1

A. Y.-C. Mo, H. Kincross, X. Wang, L. Y.-T. Chang, G. Duns, F. Mey, Z. Zhu, H. Kwan, T. Lau, T. R. Docking, J. Tran, S. Colborne, S.-W. G. Cheng, S. Huang, N. Gharaee, , A. Karsan

This study identifies FBXO11 loss as a driver of AML by promoting a stem cell program through mitochondrial dysregulation.

bioRxiv · Sep 10, 2022 · PreprintCancer Biology

DYNLL1 mis-splicing is associated with replicative genome instability in SF3B1 mutant cells

A. S. Tam, S. Tsai, E. Y.-C. Chang, V. Mathew, A. Shanks, T. R. Docking, A. Kumar, D. G. Bernard, A. Karsan, P. C. Stirling

This study shows SF3B1 mutations cause DYNLL1 mis-splicing, leading to genome instability through altered DNA repair and PARP inhibitor sensitivity.

bioRxiv · May 26, 2021 · PreprintCell Biology

TIRAP drives myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the marrow microenvironment

R. Ibrahim, A. Gopal, M. Fuller, P. Umlandt, L. Chang, J. Wegrzyn-Woltosz, J. Lam, J. Li, M. Lu, J. Parker, A. Karsan

This paper identifies TIRAP as a driver of myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the bone marrow microenvironment, independent of T cell function or pyroptosis.

bioRxiv · Feb 26, 2020Cancer Biology