Author

H.-C. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. Drennan· 1 shared C. K. Cimperman· 1 shared C. McNerney· 1 shared C.-C. Kuo· 1 shared C.-F. Kao· 1 shared C.-L. Hsieh· 1 shared C.-Y. Liu· 1 shared C.-Y. Wei· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiochemistry

A. Drennan

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Author profile →

5 papers

Recent·Most cited

Structural and functional analyses of viral H2 protein of the vaccinia virus entry fusion complex

C.-F. Kao, C.-Y. Liu, C.-L. Hsieh, K. J. D. Carillo, D.-L. M. Tzou, H.-C. Wang, W. Chang

This study determines the structure and function of the H2 protein in the vaccinia virus entry fusion complex, identifying key regions involved in membrane fusion and complex formation.

bioRxiv · Aug 28, 2023Microbiology

Roles of Clamp Closing and Allosteric Effects of Discriminator and Upstream Interactions on Downstream Elements in Stabilizing an E. coli RNA Polymerase-Promoter Open Complex

H.-C. Wang, K. M. Stroncek, T. Record

The paper investigates how discriminator sequences and upstream elements influence the stability of E. coli RNA polymerase-promoter open complexes by analyzing OC lifetimes and free energy changes.

bioRxiv · Apr 18, 2022 · PreprintBiophysics

Fluorescence-Detected Conformational Changes in Duplex DNA in Open Complex Formation by E. coli RNA Polymerase: Upstream Wrapping and Downstream Bending Precede Clamp Opening and Insertion of the Downstream Duplex

R. Sreenivasan, I. A. Shkel, M. Chhabra, A. Drennan, S. Heitkamp, H.-C. Wang, M. A. Sridevi, D. Plaskon, C. McNerney, K. Callies, C. K. Cimperman, M. T. Record

This study uses FRET and PIFE to analyze DNA conformational changes during E. coli RNA polymerase open complex formation, revealing upstream wrapping and downstream bending before clamp opening.

bioRxiv · Feb 4, 2020Biochemistry

Invasive plants facilitated by socioeconomic change shelter vectors of scrub typhus and spotted fever

C.-Y. Wei, J.-K. Wang, H.-C. Shih, H.-C. Wang, C.-C. Kuo

This study shows that invasive plants, driven by socioeconomic changes, create habitats that support higher populations of disease vectors, increasing the risk of scrub typhus and spotted fever.

bioRxiv · Jun 5, 2019Ecology

Low-Density Lipoprotein Receptor-Mediated Lipidome-Transcriptome Reprogramming Impulses to Cisplatin Insensitivity

W.-C. Chang, H.-C. Wang, W.-C. Cheng, J.-C. Yang, W.-M. Chung, L. Chen, Y.-P. Ho, Y.-C. Hung, W.-L. Ma

This study identifies LDLR-mediated lipidome-transcriptome reprogramming as a mechanism for cisplatin insensitivity in ovarian cancer and demonstrates a lipid-based drug delivery strategy to enhance chemotherapy efficacy.

bioRxiv · Dec 21, 2018 · PreprintCancer Biology