F. Halbritter

YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells

The paper shows that IGF-1 reprograms bone mesenchymal stem cells in EWS::FLI1-mutant mice, leading to tumor formation, with Yap1 playing a central role, and suggests combined IGF-1R and YAP/TEAD inhibition as a potential treatment.

Natural killer cell cytotoxicity shapes the clonal evolution of B cell leukaemia

This study shows NK cells influence all phases of cancer immunoediting in B-ALL, promoting resistant clones through selective pressure and identifying LY6E as a marker of poor prognosis.

Cross-species analysis identifies conserved transcriptional mechanisms of neutrophil maturation

The paper identifies conserved transcriptional mechanisms of neutrophil maturation across zebrafish, mouse, and human by generating high-resolution transcriptional profiles and cross-species comparisons.

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations

The paper uses human embryonic stem cells to show that chromosomal gains in neuroblastoma impair neural crest development and enhance MYCN-driven tumourigenesis.

Automated compound testing in zebrafish xenografts identifies combined MCL-1 and BCL-XL inhibition to be effective against Ewing sarcoma

Single-cell landscape of bone marrow metastases in human neuroblastoma unraveled by deep multiplex imaging

This study uses deep multiplex imaging to create a single-cell atlas of bone marrow metastases in neuroblastoma, revealing tumor heterogeneity and microenvironmental changes.

Distinct SoxB1 networks are required for naïve and primed pluripotency

The paper shows that distinct SoxB1 networks support naïve and primed pluripotency, with different expression balances of Sox2 and Sox3 in ESCs and EpiSCs.