M. Lopes

An optimized and robust workflow for quantifying the canonical histone ubiquitination marks H2AK119ub and H2BK120ub by LC-MS/MS

The paper develops a robust LC-MS/MS workflow for quantifying H2AK119ub and H2BK120ub histone ubiquitination marks, improving upon existing methods for C-terminal modifications.

Fusion of blood vessel organoids with human pancreatic islets improves insulin response over time.

This study fuses blood vessel organoids with human pancreatic islets, showing improved insulin response over time in two donors.

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

This study identifies H2AX's role in promoting replication fork degradation and chemosensitivity in BRCA-deficient tumours, independent of its classical DNA damage signalling function.

TGFβ controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription

This study shows TGFβ signaling is essential for maintaining alveolar type 1 cell fate and regulates the alveolar matrisome through integrin transcription and mechanotransduction.

Replication fork plasticity upon replication stress requires rapid nuclear actin polymerization

This study shows that nuclear actin polymerization enables replication fork plasticity by facilitating fork slowing and reversal during replication stress.

Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency

The paper develops MATAC-Seq to analyze single-molecule chromatin accessibility at replication origins, identifying chromatin features that predict origin efficiency in yeast.

Stable Isotope Tracing In Vivo Reveals A Metabolic Bridge Linking The Microbiota To Host Histone Acetylation

This study uses stable isotope tracing to show that gut microbiota supply carbon for host histone acetylation, linking microbial metabolism to host epigenetic regulation.

Fork Slowing and Reversal as an Adaptive Response to Chronic ATR Inhibition

This study investigates the effects of chronic low-dose ATR inhibition on replication dynamics, revealing fork reversal as an adaptive response that enhances cell survival and can be exploited to improve cancer therapies.

Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications

The paper investigates iron metabolism in AML, finding that AML causes iron redistribution through erythroblast loss, leading to high TSAT and improved survival.

THAP11F80L cobalamin disorder-associated mutation reveals normal and pathogenic THAP11 functions in gene expression and cell proliferation

The paper investigates THAP11 functions in gene expression and cell proliferation, showing that the THAP11F80L mutation causes altered gene expression and reduced MMACHC transcription, linking it to cobalamin disorder.

Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival During Cancer Cachexia Syndrome

This study shows that disrupting TLR4 reduces adipose tissue remodeling and improves survival in cancer cachexia by inhibiting inflammation and macrophage infiltration.

Unraveling rice tolerance mechanisms against Schizotetranychus oryzae mite infestation

This study compares two rice cultivars, Puita INTA-CL and IRGA423, to identify tolerance mechanisms against Schizotetranychus oryzae mite infestation, finding IRGA423 exhibits tolerance through multiple defense-related pathways.