PhysiologybioRxiv
Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury
G. A. Gusarova, S. Das, M. N. Islam…·J. Bhattacharya
The paper shows that exogenous V12Rac1 enhances alveolar F-actin and prevents TNFR1 surge, reducing mortality in ALI caused by LPS or Pseudomonas aeruginosa.
DOI 10.1172/jci.insight.135753