G. Jin

Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability

This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.

Induction of immortal-like and functional CAR-T cells by defined factors

This study identifies factors that induce CAR-T cells with stem-like properties, enhancing their long-term persistence and antitumor efficacy in vivo.

One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice

This paper shows that engineered T cells can cure asthma in mice by targeting eosinophils and blocking inflammatory cytokines.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

Phospholipase A2 activity is required for immune defense of European (Apis mellifera) and Asian (Apis cerana) honeybees against the American foulbrood pathogen, Paenibacillus larvae

This study shows that phospholipase A2 activity is essential for immune defense in European and Asian honeybees against Paenibacillus larvae, with PLA2A and PLA2B specifically inhibiting immune responses.

Latitudinal scaling of aggregation with abundance and its consequences for coexistence in species rich forests

The paper examines latitudinal patterns in species aggregation and abundance, showing how these patterns affect coexistence in forests and introduces a framework to model their impact on extinction risk.

Latitude influences stability via stabilizing mechanisms in naturally-assembled forest ecosystems at different spatial grains

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

A latitudinal pattern of plant leaf-associated bacterial community assembly

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy

This study engineers CAR-expressing neutrophils from human pluripotent stem cells, showing enhanced anti-tumor activity against glioblastoma in vitro and in vivo.

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

The PD-L1 and TLR7 dual-targeting nanobody-drug conjugate exerts potent antitumor efficacy by orchestrating innate and adaptive immune responses

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury

The paper shows that exogenous V12Rac1 enhances alveolar F-actin and prevents TNFR1 surge, reducing mortality in ALI caused by LPS or Pseudomonas aeruginosa.

CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreatitis

This study identifies CVB3 VP1 as an inhibitor of cell proliferation by disrupting MAT1 interaction with the CAK complex, thereby blocking CAK-CDK4/6-Rb signaling in pancreatic cells.

Antibody Escape by Polyomavirus Capsid Mutation Facilitates Neurovirulence

The paper shows a JCPyV-PML VP1 mutation enables antibody escape and neurovirulence in mice.

Species packing and the latitudinal gradient in beta-diversity

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

Molecular mechanism of SARS-Cov-2 components caused ARDS in murine model

This study develops a non-infectious murine model to study SARS-CoV-2-induced ARDS and CSS, and identifies potential therapeutic agents that alleviate inflammatory symptoms.

Foundation species across a latitudinal gradient in China

The paper identifies candidate foundation species in Chinese forests across a latitudinal gradient and finds they are more common in temperate zones than in tropical or boreal regions.

Tuber yield and processing quality response of French fried potatoes to nitrogen fertilization

This study evaluates how different nitrogen fertilizer rates affect tuber yield and processing quality of two potato cultivars, finding optimal rates for high yield and quality.

Kaposi sarcoma-associated herpesvirus infection in HIV patients: potential role of HIV-associated extracellular vesicles

This study shows HIV-associated extracellular vesicles enhance KSHV infectivity in oral epithelial cells via TAR RNA and EGFR, suggesting EGFR inhibition as a potential therapeutic strategy.

phospho-ERK is a response biomarker to a combination of sorafenib and MEK inhibition in liver cancer

This study identifies phospho-ERK as a biomarker for response to sorafenib and MEK inhibition in liver cancer, showing synergistic effects in tumors with high phospho-ERK levels.