I. P. Newton

This paper demonstrates a capsule device that uses focused ultrasound and microbubbles to deliver fluorescent markers through the mucus layer of the porcine small intestine.

This study shows that loss of Apc function in intestinal epithelial cells reduces IL-22 receptor expression and STAT3 activation, leading to resistance to IL-22 and increased genetic instability.

The paper identifies APC interaction partners and β-catenin-independent targets using proteomics, revealing MINK1 as a potential substrate of an alternative APC destruction complex.

The paper shows that postmitotic separation of intestinal crypt cells leads to niche retention of one daughter cell, and this process is disrupted in Apc mutant cells.