D. Wrapp

HLA-E-VL9 antibodies enhance NK cell and CD8+ T cell cytotoxicity against HIV-infected CD4+ T cells

This study develops anti-HLA-E-VL9 antibodies that enhance NK and CD8+ T cell cytotoxicity against HIV-infected cells by blocking NKG2A/CD94 interactions and promoting ADCC.

Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes

This study designs engineered immunogens targeting conserved coronavirus epitopes to elicit broad-spectrum antibodies, showing protection in mice against live virus challenge.

Structure-based stabilization of SOSIP Env enhances recombinant ectodomain durability and yield

This paper introduces a proline-stabilization strategy (2P) to enhance the durability and yield of recombinant HIV-1 Env trimers without altering their antigenic or conformational properties.

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

This paper identifies NTD-targeting neutralizing antibodies and shows that combining RBD and NTD antibodies reduces the emergence of neutralization-escape mutants.

Efficient discovery of potently neutralizing SARS-CoV-2 antibodies using LIBRA-seq with ligand blocking

This study demonstrates that integrating ligand blocking into LIBRA-seq improves the efficiency of identifying potent SARS-CoV-2 neutralizing antibodies.

Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognition

This study identifies a potent SARS-CoV-2 antibody, 54042-4, that neutralizes variants of concern and has a unique epitope and genetic structure.

Structural basis for HCMV Pentamer recognition by antibodies and neuropilin 2

This study determines the cryo-EM structure of HCMV Pentamer bound to neuropilin 2 and neutralizing antibodies, revealing molecular interactions and epitopes involved in viral tropism and neutralization.

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

The paper identifies cross-reactive antibodies against multiple coronaviruses, showing they target diverse epitopes and mediate effector functions.

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

This study engineers an antibody, ADG-2, that broadly neutralizes SARS-CoV and SARS-CoV-2 in mice, offering protection against respiratory disease and viral replication.

Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes

This study designs and characterizes prefusion-stabilized SARS-CoV-2 spike variants to improve protein yield and stability for vaccine and diagnostic development.

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses, highlighting a conserved epitope on the spike protein as a potential vaccine target.

Local computational methods to improve the interpretability and analysis of cryo-EM maps

The paper introduces local computational methods to improve cryo-EM map interpretability by avoiding over-sharpening and providing local B-factors and occupancy maps.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies

This study isolates and characterizes VHH antibodies that neutralize MERS-CoV, SARS-CoV-1, and SARS-CoV-2 by blocking receptor binding, with structural insights into their epitopes and cross-reactivity.

Site-specific analysis of the SARS-CoV-2 glycan shield

The paper uses mass spectrometry to analyze glycan structures on the SARS-CoV-2 spike protein, revealing differences from host glycan processing and implications for vaccine design.

Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation

The paper determines the cryo-EM structure of the 2019-nCoV Spike protein in the prefusion conformation and shows higher ACE2 binding affinity compared to SARS-CoV.

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection

This study characterizes non-neutralizing gB-specific monoclonal antibodies from HCMV-infected individuals, revealing their binding specificity, genotype preference, and effector functions like ADCP and ADCC.

Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

This study uses cryo-EM to show that ACE2 binding and trypsin cleavage of SARS-CoV spike protein do not cause major conformational changes or expose the S2 cleavage site.