J. Boot

TLR5 drives metabolic dysfunction-associated steatohepatitis through lipid- and flagellin-induced hepatocyte injury signalling

The paper investigates TLR5's role in MASH and fibrosis using clinical data, single-cell transcriptomics, and in vitro models, finding TLR5 drives hepatocyte injury and fibrosis through flagellin and lipid pathways.

Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets.

The paper identifies epigenetic regulation of key pathways and novel druggable targets in glioblastoma by comparing chromatin remodelling in neoplastic and neural stem cells.

Multi-parameter phenotyping of platelets and characterisation of the effects of agonists using machine learning

This paper uses multi-parameter flow cytometry and machine learning to characterize platelet sub-populations and their responses to agonists, achieving high accuracy in distinguishing platelet age and activation states.

Global hypo-methylation in a subgroup of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

The paper identifies a glioblastoma subgroup with global hypo-methylation and astrocytic features linked to invasion and immune changes.