Author

H. Malik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Cocco· 1 shared A. D. S. Filipe· 1 shared A. Goralcyzk· 1 shared A. Nelson· 1 shared A. Taggart· 1 shared B. Chen· 1 shared B. Roberts· 1 shared C. Boutell· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMicrobiology

A. Cocco

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

TLR5 drives metabolic dysfunction-associated steatohepatitis through lipid- and flagellin-induced hepatocyte injury signalling

W. Li, N. Wang, R. Kumar, I. Gines Mir, U. Gill, G. Hood, J. Brindley, C. Mein, J. Boot, R. Wilcox, N. Dufton, R. Goldin, J. Loy, K. Devalia, H. Malik, , W. Alazawi

The paper investigates TLR5's role in MASH and fibrosis using clinical data, single-cell transcriptomics, and in vitro models, finding TLR5 drives hepatocyte injury and fibrosis through flagellin and lipid pathways.

bioRxiv · Feb 7, 2026 · PreprintMolecular Biology

A Machine Learning Framework to Identify the Correlates of Disease Severity in Acute Arbovirus Infection

V. Herder, M. Caporale, O. MacLean, D. Pintus, X. Huang, K. Nomikou, N. Palmalux, J. Nichols, R. Scivoli, C. Boutell, A. Taggart, J. Allan, H. Malik, G. Ilia, Q. Gu, , M. Palmarini

This study uses machine learning to identify key viral and host processes associated with varying severity in bluetongue virus infection in sheep.

bioRxiv · Feb 23, 2024 · PreprintMicrobiology

Cardiac MAO-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control

Q. Shi, H. Malik, J. Streeter, J. Wang, R. Huo, R. M. Crawford, J. C. Shih, B. Chen, D. Hall, E. D. Abel, L.-S. Song, E. J. Anderson

This study shows that inhibiting MAO-A in cardiomyocytes reduces arrhythmias by improving diastolic calcium control following catecholamine stress.

bioRxiv · Sep 29, 2022Physiology

Anthropogenic disturbance impacts gut microbiome homeostasis in a Malagasy primate

Wasimuddin, H. Malik, Y. R. Ratovonamana, S. J. Rakotondranary, J. U. Ganzhorn, S. Sommer

This study shows that anthropogenic disturbances reduce gut microbiome diversity and alter microbial composition in Malagasy lemurs, potentially impacting their health and survival.

bioRxiv · Apr 2, 2022Microbiology

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

K. Kato, S. Ahmad, Z. Zhu, J. Young, X. Mu, S. Park, H. Malik, s. Hur

The paper reveals conserved interaction rules between RNA helicases and TRIM E3 ligases in vertebrate innate immunity using cryo-EM and biochemistry.

bioRxiv · Aug 26, 2020Biochemistry

Scarless gene tagging of transcriptionally silent genes in hiPSCs to visualize cardiomyocyte sarcomeres in live cells

B. Roberts, J. Arakaki, K. A. Gerbin, H. Malik, A. Nelson, M. C. Hendershott, C. Hookway, S. A. Ludmann, I. A. Mueller, R. Yang, S. M. Rafelski, R. N. Gunawardane

The paper describes a CRISPR/Cas9 method to tag transcriptionally silent genes in hiPSCs with mEGFP, enabling visualization of sarcomeric proteins in live cardiomyocytes.

bioRxiv · Jun 9, 2018Cell Biology