Author

A. J. Samelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

M. Kampmann· 2 shared R. Tian· 2 shared A. Mac Kain· 1 shared A. Steward· 1 shared B. Conklin· 1 shared B. R. TenOever· 1 shared C. Parra Bravo· 1 shared D. Eisenberg· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

M. Kampmann

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

A. J. Samelson, N. Ariqat, J. McKetney, G. Rohanitazangi, C. Parra Bravo, R. Bose, K. J. Travaglini, V. L. Lam, D. Goodness, G. Dixon, E. Marzette, J. Jin, R. Tian, E. Tse, R. Abskharon, , M. Kampmann

The paper uses CRISPR screens in iPSC-derived neurons to identify factors controlling tau aggregation, finding new pathways and potential therapeutic targets for tauopathies.

bioRxiv · Jun 16, 2023Cell Biology

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2

A. J. Samelson, Q. D. Tran, R. Robinot, L. Carrau, V. V. Rezelj, A. Mac Kain, M. Chen, G. N. Ramadoss, X. Guo, S. A. Lim, I. Lui, J. Nunez, S. J. Rockwood, J. Wang, N. Liu, , M. Kampmann

This study identifies BRD2 as a regulator of ACE2 transcription and shows that BRD2 inhibitors block SARS-CoV-2 infection in human cells and animal models.

bioRxiv · Jan 19, 2021Cell Biology

The folding and unfolding behavior of ribonuclease H on the ribosome

M. K. Jensen, A. J. Samelson, A. Steward, J. Clarke, S. Marqusee

This study investigates how the ribosome affects the folding and unfolding of RNase H during translation, finding that ribosome-stalled RNase H unfolds faster but maintains the same folding rate.

bioRxiv · Apr 16, 2020Biophysics