Author

J. D. Kirkpatrick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:proteomics· 3 Research Focus:cell-cell communication· 2 Assay:imaging· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. P. Soleimany· 3 shared Q. Zhong· 3 shared S. N. Bhatia· 3 shared S. Su· 2 shared T. Jacks· 2 shared A. Aung· 1 shared A. Bekdemir· 1 shared A. Cui· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioengineering

A. P. Soleimany

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Author profile →

4 papers

Recent·Most cited

Inhalable point-of-care urinary diagnostic platform

Q. Zhong, E. K. W. Tan, C. Martin-Alonso, T. Parisi, L. Hao, J. D. Kirkpatrick, T. Fadel, H. Fleming, T. Jacks, S. N. Bhatia

This paper introduces a point-of-care diagnostic platform for lung cancer using inhalable nanosensors that detect tumor-associated proteases through urine analysis.

bioRxiv · Sep 30, 2023Bioengineering

Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens

A. Aung, A. Cui, A. P. Soleimany, M. Bukenya, H. Lee, C. A. Cottrell, M. Silva, J. D. Kirkpatrick, P. Amlashi, T. K. Remba, S. Xiao, L. M. Froehle, W. Abraham, J. Adams, H. Suh, , J. R. Gregory

The paper shows that spatially restricted protease activity in lymph node follicles preserves antigen integrity, leading to stronger GC responses when antigens are targeted to follicular dendritic cells.

bioRxiv · Nov 15, 2021 · PreprintImmunology

Multiscale profiling of enzyme activity in cancer

A. P. Soleimany, J. D. Kirkpatrick, C. S. Wang, A. M. Jaeger, S. Su, S. Naranjo, Q. Zhong, C. M. Cabana, T. Jacks, S. Bhatia

This paper develops methods to measure enzyme activity in cancer across multiple scales, revealing protease dysregulation and dynamic interactions between tumor cells and their microenvironment.

bioRxiv · Nov 11, 2021 · PreprintBioengineering

Activatable zymography probes enable in situ localization of protease dysregulation in cancer

A. P. Soleimany, J. D. Kirkpatrick, S. Su, J. S. Dudani, Q. Zhong, A. Bekdemir, S. N. Bhatia

This paper introduces activatable zymography probes (AZPs) to detect protease activity in cancer tissues, demonstrating their utility in classifying disease and guiding therapeutic design.

bioRxiv · Jul 29, 2020Bioengineering