Author

J. Che

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:deep learning· 1

Frequent Co-Authors

J. Tse· 2 shared T. Zhang· 2 shared W. Lu· 2 shared Z. He· 2 shared A. Chakravarty· 1 shared A. S. Boghossian· 1 shared C. Liu· 1 shared E. A. Geffken· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

J. Tse

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

Z. Li, H.-Y. Liu, Z. He, A. Chakravarty, R. P. Golden, Z. Jiang, I. You, H. Yue, K. A. Donovan, G. Du, J. Che, J. Tse, I. Che, W. Lu, E. S. Fischer, , P. L. Yang

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

Advanced Science · Aug 15, 2024Peer-reviewedBiochemistry

Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

X. Zhang, G. Zhang, S. Sang, Y. Fei, X. Cao, W. Song, F. Liu, J. Che, H. Tao, H. Wang, L. Zhang, Y. Guan, S. Rong, L. Pei, S. Yao, , C. Liu

This study analyzes single-cell transcriptomes of gastric cancer with and without H. pylori infection to identify immune and angiogenic signatures predictive of immunotherapy response.

bioRxiv · May 31, 2024 · PreprintCancer Biology

A comprehensive landscape of the zinc-regulated human proteome

N. Burger, M. Mittenbuhler, H. Xiao, S. Shin, L. Bozi, S. Wei, H.-G. Sprenger, Y. Sun, Y. Zhu, N. Darabedian, J. Petrocelli, P. Latorre Muro, J. Che, E. T. Chouchani

This study maps zinc-regulated cysteine sites in the human proteome, identifies cancer dependencies, and reveals a mechanism of zinc-induced cytotoxicity in lung cancers.

bioRxiv · Jan 4, 2024 · PreprintCell Biology

Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling

M. Fan, W. Lu, J. Che, N. P. Kwiatkowski, Y. Gao, H.-S. Seo, S. B. Ficarro, P. C. Gokhale, Y. Liu, E. A. Geffken, J. Lakhani, K. Song, M. Kuljanin, W. Ji, J. Jiang, , N. Gray

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

bioRxiv · May 10, 2022Cancer Biology