M. Fan

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

Comprehensive Multi-Omic Analysis Reveals Distinct Molecular Features in Early and Advanced Stages of Hepatocellular Carcinoma

This study uses multi-omic analyses to identify molecular features and biomarkers in early and advanced hepatocellular carcinoma stages.

Scalable bio-platform to recover critical metals fromcomplex waste sources

This study demonstrates a scalable bio-platform using Methylobacterium extorquens to recover critical metals from complex waste sources without harsh chemicals.

The Legionella autoinducer LAI-1 is delivered by outer membrane vesicles to promote inter-bacterial and inter-kingdom signaling

This paper identifies LAI-1 as a signaling molecule secreted by Legionella pneumophila via outer membrane vesicles, promoting inter-bacterial and inter-kingdom communication.

KARS mediates intra-translational deposition of N6-acetyl-L-lysine in nascent proteins to contribute the acetylome in cells

The paper identifies KARS as mediating intra-translational deposition of N6-acetyl-L-lysine in nascent proteins, contributing to the acetylome in mice.

Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

HIF-dependent expression of creatine kinase brain isoform (CKB) promotes breast cancer metastasis, whereas cyclocreatine therapy impairs invasion and improves the efficacy of conventional chemotherapies

This study identifies CKB as a HIF-1 downstream gene promoting breast cancer metastasis and shows cyclocreatine therapy reduces invasion and enhances chemotherapy efficacy.

Disruption of Brachypodium Lichenase Alters Metabolism of Mixed-linkage Glucan and Starch

This study identifies BdLCH1, a lichenase in Brachypodium, and shows its role in MLG degradation in vegetative tissues and starch breakdown in darkness.

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts

This study develops a platform combining deep learning and high-content imaging to identify disease-specific phenotypes in Parkinson's fibroblasts, achieving high accuracy in distinguishing disease subtypes.

Single-cell immune landscape of human recurrent spontaneous abortion

This study uses single-cell RNA-sequencing to analyze decidual and peripheral leukocytes in normal and RSA pregnancies, revealing immune dysregulation in RSA.

BNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia

This study shows that JNK1/2 phosphorylates BNIP3 under hypoxia, enhancing its stability and promoting mitophagy by increasing its binding to LC3.

Myelin water imaging depends on white matter fiber orientation in the human brain

This study shows that myelin water fraction varies with white matter fiber orientation and TR selection, affecting MWF estimation and interpretation.

A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens

The paper develops a semi-supervised machine learning method to classify drug-induced morphological changes in malaria parasite cultures, enabling clustering of drugs by mechanism of action.

Differential functions of splicing factors in breast-cancer initiation and metastasis

This study identifies splicing factors involved in breast cancer initiation and metastasis, showing their differential roles and interactions with MYC.

SCFAs-induced GLP-1 Secretion Links the Regulation of Gut Microbiome on Hepatic Lipogenesis in Chickens

This study shows that SCFAs from gut microbiota stimulate GLP-1 secretion in chickens, which suppresses hepatic lipogenesis.

Improved yield of AAV2 and rAAV2-retro serotypes following sugar supplementation during the viral production phase

This study shows that adding sucrose or sorbitol during AAV production increases yields of AAV2 and rAAV2-retro serotypes by 1.8-fold and 1.5-fold, respectively, without affecting purity or infectivity.

Transplantation of human pluripotent stem cells overexpressing insulin/ERRγ can efficiently decrease the HbA1c levels of type 2 diabetes patient (Case #2-A)