Cancer BiologybioRxiv
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation
T. Somerville, G. Biffi, J. Dassler-Plenker…·C. Vakoc
This study shows that squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation by converting pancreatic stellate cells into inflammatory CAFs via TP63-dependent mechanisms.
DOI 10.7554/elife.53381