Author

M. Egeblad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

A. Pommier· 2 shared A. S. Almeida· 2 shared D. T. Fearon· 2 shared A. Eberhardt· 1 shared A. Gouronnec· 1 shared A. Nemajerova· 1 shared A. P. Delgado· 1 shared A. Wuest· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

A. Pommier

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

H.-A. Chen, Y.-J. Ho, R. Mezzadra, J. M. Adrover, R. M. Smolkin, C. Zhu, L. Wei, A. Wuest, S. Tian, X. Li, R. C. Hendrickson, M. Egeblad, D. Alonso-Curbelo, S. W. Lowe

The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.

bioRxiv · Jun 4, 2022Cancer Biology

Single-cell transcriptome analysis reveals evolutionarily conserved features during the transition from normal breast stromal cells to cancer-associated fibroblasts

A. P. Delgado, A. Nemajerova, B. J. Nelson, M. Rao, J. Li, N. Marchenko, J. Preall, U. M. Moll, M. Egeblad, S. Powers

This study identifies conserved CAF subtypes in human and mouse breast tissues and reveals shared molecular mechanisms in their transition from normal stromal cells.

bioRxiv · May 5, 2022 · PreprintCancer Biology

Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis

L. Sun, T. Kees, A. S. Almeida, B. Liu, X.-Y. He, D. Ng, D. Spector, I. M. McNeish, P. Gimotty, S. Adams, M. EGEBLAD

This study shows that combining MPLA and IFNγ reprograms macrophages to kill cancer cells and reduce metastasis in breast and ovarian cancer models.

Cancer Cell · Oct 1, 2021Peer-reviewedCancer Biology

Cancer cell CCR2 orchestrates suppression of the adaptive immune response

M. R. Fein, X. Y. He, A. S. Almeida, E. Bruzas, A. Pommier, R. Yan, A. Eberhardt, D. T. Fearon, L. Van Aelst, J. E. Wilkinson, C. O. dos Santos, M. Egeblad

This study shows that CCR2 in cancer cells suppresses immune response by reducing CD103+ dendritic cell recruitment and altering immune cell infiltration and activation.

bioRxiv · Dec 27, 2019Cancer Biology

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

T. Somerville, G. Biffi, J. Dassler-Plenker, K. Miyabayashi, Y. Xu, D. Maia-Silva, O. Klingbeil, O. Demerdash, M. Egeblad, D. Tuveson, C. Vakoc

This study shows that squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation by converting pancreatic stellate cells into inflammatory CAFs via TP63-dependent mechanisms.

bioRxiv · Nov 6, 2019Cancer Biology

Endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

A. Pommier, N. Anaparthy, N. Memos, Z. Larkin Kelley, A. Gouronnec, J. Albrengues, M. Egeblad, C. A. Iacobuzio-Donahue, S. K. Lyons, D. T. Fearon

The paper shows that endoplasmic reticulum stress enables pancreatic cancer cells to evade immune detection and form latent metastases.

bioRxiv · Sep 11, 2017Immunology