Author

J. Fallas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Assay:protein structure· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

G. Ueda· 3 shared D. Baker· 2 shared L. Carter· 2 shared M. Lamb· 2 shared N. P. King· 2 shared P. M. Levine· 2 shared S. Chan· 2 shared A. Dosey· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiochemistry

G. Ueda

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

De novo design of buttressed loops for sculpting protein functions

H. Jiang, K. M. Jude, K. Wu, J. Fallas, G. Ueda, T. Brunette, D. Hicks, H. Pyles, A. Yang, L. Carter, M. Lamb, X. Li, P. M. Levine, L. J. Stewart, K. C. Garcia, D. Baker

This paper designs proteins with structured loops supported by hydrogen bonds, demonstrating their stability and functionality in binding extended peptides.

bioRxiv · Aug 22, 2023 · PreprintBiochemistry

Antigen spacing on protein nanoparticles influences antibody responses to vaccination

D. Ellis, A. Dosey, S. Boyoglu-Barnum, Y.-J. Park, R. Gillespie, H. Syeda, Y. Tsybovsky, M. Murphy, D. Pettie, N. Matheson, S. Chan, G. Ueda, J. Fallas, L. Carter, B. Graham, , N. P. King

This study shows that antigen spacing on protein nanoparticles affects antibody responses to vaccination, with decreased spacing improving hemagglutination inhibition and neutralization potency.

bioRxiv · May 23, 2023Immunology

Computational design of non-porous, pH-responsive antibody nanoparticles

E. C. Yang, R. Divine, M. C. Miranda, A. J. Borst, W. Sheffler, J. Z. Zhang, J. Decarreau, A. Sarajovi, M. Abedi, N. Goldbach, M. Ahlrichs, C. Dobbins, A. Hand, S. Cheng, M. Lamb, , D. Baker

This paper designs pH-responsive antibody nanoparticles with three distinct protein components that disassemble at tunable pH levels, enabling targeted delivery of biologics.

bioRxiv · Apr 17, 2023Bioengineering