B. Graham

H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation

The paper shows that H3K18 and H3K23 acetylation enhance MLL1-mediated H3K4 methylation, while other modifications are less affected by tail acetylation.

Antigen spacing on protein nanoparticles influences antibody responses to vaccination

This study shows that antigen spacing on protein nanoparticles affects antibody responses to vaccination, with decreased spacing improving hemagglutination inhibition and neutralization potency.

Intracellular diversity of WNV within circulating avian peripheral blood mononuclear cells reveals host-dependent patterns of polyinfection

The paper infects avian hosts and cell lines with barcoded WNV to show that higher viremia in crows allows greater viral diversity and maintenance of rare variants through complementation, unlike in robins.

The Role of EBP50 in Regulating Endothelial-To-Mesenchymal Transition in Pulmonary Hypertension

This study shows EBP50 downregulation promotes EndMT in pulmonary hypertension by increasing Snail, Zeb1, and Slug expression, and mesenchymal markers, while reducing cell proliferation and barrier function.

Shifting a Cellular Metabolic Landscape Identifies a Refractory Environment for Flavivirus Replication

The paper identifies a refractory metabolic environment induced by fatty acid biosynthesis inhibition that limits flavivirus replication and shows that combining this with nucleotide synthesis pathway inhibition significantly reduces viral infectivity.

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

The paper identifies potent monoclonal antibodies that neutralize the B.1.1.529 SARS-CoV-2 variant and reveals structural mechanisms enabling their effectiveness.

A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice

A broadly neutralizing antibody protects against multiple SARS-CoV and SARS-CoV-2 variants in mice by targeting a conserved epitope in the receptor-binding domain.

Predicting range shifts of African apes under global change scenarios

The paper predicts future distribution shifts of African apes under climate and land-use change scenarios using ensemble forecasting and occurrence data.

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

Nanoparticle immunogens with four seasonal influenza hemagglutinins elicit neutralizing antibodies against both the head and stem, providing broad protection against diverse influenza strains.

SNAPSwitch: A Molecular Sensor to Quantify the Localization of Proteins, DNA and Nanoparticles in Cells

SNAPSwitch quantitatively tracks protein, DNA, and nanoparticle localization in live cells using flow cytometry, showing distinct trafficking routes for different receptors.

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

The paper shows that an erythroid-specific self-interacting chromatin domain forms before gene activation and does not depend on enhancer-promoter interactions.