D. Hicks

ACE2 decoy Fc-fusions and bi-specific killer engager (BiKEs) require Fc engagement for in vivo efficacy against SARS-CoV-2

This study shows that Fc receptor engagement is necessary for the efficacy of SARS-CoV-2 therapeutics, including mAbs and BiKEs, and demonstrates the effectiveness of ACE2 decoy Fc-fusions and BiKEs against multiple variants.

Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C)

This study identifies dysregulated antibody-mediated cellular responses in MIS-C, linking NK cell dysfunction to immune pathology and suggesting potential therapeutic interventions.

Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.

This study investigates the impact of substrate stiffness on C. elegans health and longevity, finding only mild effects on cellular and organismal health.

Abca4 inhibition in a cone-rich rodent leads to Stargardt Disease type 1-like retinal degeneration

This study shows that Abca4 inhibition in a cone-rich rodent model leads to retinal degeneration similar to human Stargardt Disease type 1.

De novo design of buttressed loops for sculpting protein functions

This paper designs proteins with structured loops supported by hydrogen bonds, demonstrating their stability and functionality in binding extended peptides.

Medulloblastoma Group 3 and 4 Tumors Comprise a Clinically and Biologically Significant Expression Continuum Reflecting Human Cerebellar Development

The paper shows medulloblastoma Group3 and Group4 tumors form a transcriptional continuum linked to cerebellar development, with prognostic and molecular implications.

ORA47 is a transcriptional regulator of a general stress response hub

The paper identifies ORA47 as a transcriptional regulator involved in the general stress response by interacting with the RSRE motif and functioning with CAMTA3 and JAZ1.

Dopamine 2 receptor signaling controls the daily burst in phagocytic activity in the mouse retinal pigment epithelium

This study shows that dopamine 2 receptor (D2R) is required for the daily burst of phagocytic activity in mouse retinal pigment epithelium (RPE) after light onset, as D2R knockout mice lack this burst and show altered gene expression.